N1771
去甲-Binaltorphimine 二盐酸盐
≥98% (TLC), solid, κ-opioid receptor antagonist
别名:
去甲-BNI 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C40H43N3O6 · 2HCl
化学文摘社编号:
分子量:
734.71
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
去甲-Binaltorphimine 二盐酸盐,
SMILES string
Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13
InChI
1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1
InChI key
JOJPJLHRMGPDPV-LZQROVCBSA-N
form
solid
storage temp.
−20°C
Quality Level
Gene Information
human ... OPRK1(4986)
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Biochem/physiol Actions
Highly selective k-opioid receptor antagonist. nor-Binaltorphimine has antidepressant properties.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
T K Eisenstein et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1484-1489 (1995-12-01)
An in vitro assay was used to compare the effect of opioids on antibody production by splenocytes from C3HeB/FeJ, C57BL/6J, C57BL/6ByJ and B6C3F1/J mice immunized with sheep red blood cells (SRBC). Spleen cells were removed from mice that had been
Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: Behavioral and BDNF mRNA expression studies
Zhang H, et al.
European Journal of Pharmacology, 570(1-3), 89-96 (2007)
K W Kim et al.
Life sciences, 58(19), 1671-1679 (1996-01-01)
Receptor binding studies were performed to characterize the properties of subtypes of kappa opioid receptors in membrane preparations of human cerebral cortex. [3H]U69,593 ([3H]U69), a selective kappa 1-agonist, and [3H]diprenorphine ([3H]DIP), a non-selective opioid antagonist, in the presence of 1
Aaron L Cone et al.
iScience, 26(7), 107241-107241 (2023-07-24)
Opioid receptors, including the kappa opioid receptor (KOR), exert control over thermoregulation and feeding behavior. Notably, activation of KOR stimulates food intake, leading to postulation that KOR signaling plays a central role in managing energy intake. KOR has also been
J G Wettstein et al.
Pharmacology, biochemistry, and behavior, 53(2), 411-416 (1996-02-01)
The antinociceptive effects of mu and kappa agonists were examined after the systemic administration of the opioid antagonists nor-binaltorphimine (nor-BNI) and naloxone in the late response or tonic nociceptive phase of the mouse formalin assay. Initially, SC morphine (ED50, 0.97
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