N170
NS 1619
powder
别名:
1,3-二氢-1- [2-羟基-5-（三氟甲基）苯基]-5-（三氟甲基）-2H-苯并咪唑-2-酮
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关于此项目
经验公式（希尔记法）:
C15H8F6N2O2
化学文摘社编号:
分子量:
362.23
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
NS 1619, powder
InChI
1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
SMILES string
Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F
InChI key
YLFMCMWKHSDUCT-UHFFFAOYSA-N
form
powder
color
white
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
ethanol: 26.6 mg/mL
0.1 M NaOH: 5.2 mg/mL
DMSO: 5.3 mg/mL
H2O: insoluble
Quality Level
Gene Information
mouse ... Kcnma1(16531)
rat ... Kcnma1(83731)
相关类别
Application
NS 1619 已被用作钙激活钾通道(BK)-激活剂：研究其对小鼠胸主动脉环的血管舒张作用，评估其对骨骼肌肌浆/内质网Ca2+-ATP酶（SERCA）活性的作用，测定其对小鼠脑肿瘤微血管内皮细胞中caveolin-1 蛋白表达的作用
Biochem/physiol Actions
NS 1619 是选择性大电导 Ca 2+ 激活的 K + 通道激活剂。该化合物以其血管扩张属性抗增殖特性而闻名。研究表明，NS 1619 对心肌缺血再灌注损伤具有保护作用。
NS-1619可以促进心肌细胞中线粒体活性氧（ROS）的形成。它可增加培养的脑片中ROS的形成。NS-1619具有增强野生型（WT）动物中HO-1活性的能力。
Disclaimer
光敏性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Vincenzo Calderone et al.
Naunyn-Schmiedeberg's archives of pharmacology, 375(1), 73-80 (2007-01-05)
Large-conductance calcium-activated potassium channels (BK) of smooth muscle play a role in the relevant modulation of vascular tone, due to their calcium- and voltage-dependent mechanisms of activation. A potential role of endothelial BK channels has also been suggested by approaches
Yajun Liu et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G44-G54 (2011-09-17)
The objectives of this study were to determine whether neutrophil depletion with anti-neutrophil serum (ANS) or preconditioning with the hydrogen sulfide (H(2)S) donor NaHS (NaHS-PC) 24 h prior to ischemia-reperfusion (I/R) would prevent postischemic mitochondrial dysfunction in rat intestinal mucosa
S P Olesen et al.
European journal of pharmacology, 251(1), 53-59 (1994-01-04)
Activators and blockers of specific ion channels are important pharmacological tools for characterizing ion channels and their influence on cell function. The large-conductance Ca(2+)-dependent K+ channel (BK channel) is blocked by peptides such as charybdotoxin and iberiotoxin, but no selective
The potassium channel opener NS1619 modulates calcium homeostasis in muscle cells by inhibiting SERCA
Antoni Wrzosek
Cell Calcium (2014)
Rui-Ping Cai et al.
Journal of the neurological sciences, 369, 109-118 (2016-09-23)
NS1619, a calcium-activated potassium channel (Kca channel) activator, can selectively and time-dependently accelerate the formation of transport vesicles in both the brain tumor capillary endothelium and tumor cells within 15min of treatment and then increase the permeability of the blood-brain
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