推荐产品
表单
solid
质量水平
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
yellow
溶解性
DMSO: soluble
H2O: soluble (with the addition of 0.1 N HCl)
ethanol: soluble
储存温度
−20°C
SMILES字符串
[H][C@@]12Oc3c(O)ccc4C[C@H]5N(CC[C@@]1(c34)[C@@]5(O)CC\C2=N/NC(=O)c6ccccc6)CC=C
InChI
1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/b27-18+/t20-,23+,25+,26-/m1/s1
InChI key
AKXCFAYOTIEFOH-XTNAHFASSA-N
基因信息
human ... OPRK1(4986) , OPRL1(4987) , OPRM1(4988)
生化/生理作用
Agonist for κ3 opioid receptors; antagonist for ORL1 and μ opioid receptors.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Veronica Cox et al.
Neuropharmacology, 48(2), 228-235 (2005-02-08)
Naloxone benzoylhydrazone (NalBzoH) is a ligand used to study opioid receptors. It has been suggested to act at a novel kappa3 receptor but also appears to bind to classical opioid receptors, and possibly the ORL1 receptor. We have used opioid
D Ichikawa et al.
Neuroreport, 12(8), 1757-1761 (2001-06-21)
J-113397 (1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one) is a recently developed antagonist of the opioid receptor-like 1 (ORL1) receptor. We compared the in vitro functional profile J-113397 on [35S]guanosine 5'-O-(gamma-thio)triphosphate (GTPgammaS) binding to mouse brain with that of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 and naloxone benzoylhydrazone (NalBzoH). J-113397 antagonized
Eve Salonius et al.
Journal of cellular physiology, 235(4), 3497-3507 (2019-09-26)
Cell therapy combined with biomaterial scaffolds is used to treat cartilage defects. We hypothesized that chondrogenic differentiation bone marrow-derived mesenchymal stem cells (BM-MSCs) in three-dimensional biomaterial scaffolds would initiate cartilaginous matrix deposition and prepare the construct for cartilage regeneration in
Maria C Olianas et al.
British journal of pharmacology, 147(4), 360-370 (2006-01-13)
1. In the present study, we examined the pharmacological activity of the putative kappa3-opioid receptor agonist naloxone benzoylhydrazone (NalBzoH) at recombinant human opioid receptors individually expressed in Chinese hamster ovary (CHO) cells and native opioid receptors present in rat striatum.
T Mamiya et al.
Journal of neural transmission (Vienna, Austria : 1996), 108(12), 1349-1361 (2002-01-26)
Here we report the involvement of nociceptin receptor in tolerance to morphine-induced antinociception and in morphine dependence. There was no different nociceptive perception and antinociceptive effects of morphine between wild-type and the nociceptin receptor knockout mice. Tolerance to morphine (10
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