所有图片(3)
About This Item
经验公式（希尔记法）:
C18H20N2O6
CAS号:
分子量:
360.36
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
>95%
表单
powder
颜色
yellow to green
溶解性
methanol: 15 mg/mL
DMSO: 17.5 mg/mL
H2O: insoluble
SMILES字符串
CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC
InChI
1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
InChI key
PVHUJELLJLJGLN-UHFFFAOYSA-N
基因信息
human ... ADORA3(140) , CACNG1(786) , KCNH1(3756) , TTR(7276)
rat ... Adora1(29290) , Adora2a(25369)
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生化/生理作用
Ca2+ channel blocker; anti-hypertensive.
储存分类代码
11 - Combustible Solids
WGK
WGK 1
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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International journal of pharmaceutics, 431(1-2), 45-52 (2012-05-01)
A novel active and multi-dose dry powder inhaler (DPI) was developed and evaluated to deliver a small quantity (100-500 μg) of pure drug without any excipient. This dry powder inhaler utilized two compressed air flows to dispense and deliver drug
Dengning Xia et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 446-454 (2012-04-10)
The amorphous-to-crystalline transformation of nitrendipine was investigated using Raman spectroscopy and X-ray powder diffraction (XRPD). The nucleation and growth rate of crystalline nitrendipine in a medium containing poly (vinyl alcohol) (PVA) and polyethylene glycol (PEG 200) were quantitatively determined using
Peng Quan et al.
International journal of pharmaceutics, 430(1-2), 366-371 (2012-04-26)
In this study, chitosan, a cationic polymer with positive charge, was introduced to modify the nanocrystals of nitrendipine with negative charge. The nanocrystals were prepared via precipitation-high pressure homogenization method. Then the nanocrystals were dispersed into chitosan solution, and the
Dewei Shang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(30), 3459-3464 (2011-10-05)
A HPLC method with on-line solid phase extraction (SPE) and DAD detection was developed for the simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat (SHR) plasma. Plasma samples (100 μL) were injected directly onto a CAPCELL MF C(8)
Swathi Voruganti et al.
European journal of drug metabolism and pharmacokinetics, 37(2), 77-81 (2011-11-22)
Pomegranate juice (PJ) is known to be a potent inhibitor of human cytochrome enzymes. The purpose of this study was to investigate the effect of acute and chronic PJ on the pharmacokinetics of oral nitrendipine (10 mg/kg) in rabbits. Male New
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