推荐产品
形式
solid
质量水平
储存条件
desiccated
颜色
off-white
溶解性
methanol: 4.5 mg/mL
H2O: 8 mg/mL
储存温度
−20°C
SMILES字符串
Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7ccccc7c6C[C@@]35O)CC8CC8
InChI
1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1
InChI key
KNJKRQXCFJCQHC-IDRHMUJXSA-N
基因信息
human ... OPRD1(4985)
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生化/生理作用
Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.
特点和优势
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
J L Nano et al.
Pflugers Archiv : European journal of physiology, 439(5), 547-554 (2000-04-14)
Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatchard analysis revealed a dissociation constant
W Bilecki et al.
European journal of pharmacology, 390(1-2), 1-6 (2000-03-10)
A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
P S Portoghese et al.
European journal of pharmacology, 146(1), 185-186 (1988-01-27)
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