N115
Naltrindole hydrochloride
≥97.5% (HPLC), solid, δ-opioid receptor antagonist
别名:
NTI hydrochloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C26H26N2O3 · HCl
化学文摘社编号:
分子量:
450.96
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Naltrindole hydrochloride, solid
SMILES string
Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7ccccc7c6C[C@@]35O)CC8CC8
InChI key
KNJKRQXCFJCQHC-IDRHMUJXSA-N
InChI
1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1
form
solid
storage condition
desiccated
color
off-white
solubility
methanol: 4.5 mg/mL
H2O: 8 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... OPRD1(4985)
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Biochem/physiol Actions
Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
J L Nano et al.
Pflugers Archiv : European journal of physiology, 439(5), 547-554 (2000-04-14)
Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatchard analysis revealed a dissociation constant
W Bilecki et al.
European journal of pharmacology, 390(1-2), 1-6 (2000-03-10)
A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
P S Portoghese et al.
European journal of pharmacology, 146(1), 185-186 (1988-01-27)
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