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用途
sufficient for 100 fluorometric tests
检测方法
fluorometric
相关疾病
neurological disorders
储存温度
−20°C
基因信息
human ... MAOA(4128) , MAOB(4129)
mouse ... MAOA(17161) , MAOB(109731)
rat ... MAOA(29253) , MAOB(25750)
一般描述
单胺氧化酶 (MAO，EC 1.4.3.4) 是一类可催化单胺氧化脱氨反应的线粒体酶。在哺乳动物中，MAO 由 MAO-A 和 MAO-B 两种同工酶组成。 MAO功能障碍被认为是造成许多神经系统疾病的原因。 体内 MAO 水平过高或过低与抑郁症、精神分裂症、药物滥用、注意力缺陷障碍、偏头痛和不规律性成熟有关。MAO 抑制剂是治疗抑郁症的主要处方药之一。
应用
单胺氧化酶活性测定试剂盒已用于评估 MAO-A（单胺氧化酶 A）、MAO-B（单胺氧化酶 B） 和 ALDH（乙醛脱氢酶）活性。
特点和优势
兼容高通量的操作系统。
适用性
可用于测定生物样品中的MAO 活性以及筛选MAO 抑制剂。可分别测定MAO-A 和 MAO-B的活性或同时测定两者的活性。
原理
单胺氧化酶测定试剂盒为测定生物样品中 MAO 酶活性提供了一种方便的荧光测定法。在试验中，MAO 与 对酪胺（MAO-A 和 MAO-B 的底物）反应，生成 H 2 O 2 ，可通过荧光法（λex = 530/λ em = 585 nm）测定。该测定方法简便、灵敏、稳定、且具有高通量适应性。单位定义：在测定条件下，一个单位的MAO每分钟催化形成1μ摩尔H 2 O 2 。
储存分类代码
10 - Combustible liquids
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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Oria V O, et al.
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Journal of medicinal chemistry, 64(4), 1989-2009 (2021-02-04)
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Molecular neurobiology, 55(8), 6755-6768 (2018-01-20)
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Renko J M, et al.
Molecular Neurobiology, 1-14 (2018)
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