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Merck
CN

MAK112

Sigma-Aldrich

精氨酸酶活性检测试剂盒

sufficient for 200 colorimetric tests

别名:

精氨酸酶检测试剂盒

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About This Item

UNSPSC代码:
12161503
NACRES:
NA.84

用途

sufficient for 200 colorimetric tests

检测方法

colorimetric

相关疾病

cancer; immunological diseases; gastrointestinal diseases

储存温度

−20°C

基因信息

一般描述

精氨酸酶是一种含锰酶,可催化精氨酸转化为尿素和鸟氨酸。大多数哺乳动物体内存在两种同种型精氨酸酶,其组织分布和亚细胞定位有所不同。精氨酸酶I是一种胞质蛋白,主要在肝脏中表达,在肝脏中催化尿素循环的第五步和最后一步。精氨酸酶II是一种线粒体蛋白,组织分布更广,其功能可包括一氧化氮和多胺代谢。精氨酸酶I的活性或表达降低可导致常染色体隐性遗传病高精氨酸血症。血清精氨酸酶活性增加与肝损伤和某些病理状态(如癌症)有关。精氨酸酶还参与免疫系统的多种炎症反应,例如巨噬细胞介导的细胞毒性。

应用

精氨酸酶活性检测试剂盒用于评估精氨酸酶的活性。

特点和优势

兼容高通量的操作系统。

适用性

该试剂盒适用于检测酶制备体系、血清、血浆、组织培养物及类似样品中的精氨酸酶活性。还可用于研究药物对精氨酸酶活性的影响。

原理

在该检测中,精氨酸酶可催化精氨酸转化成尿素和鸟氨酸。产生的尿素与底物特异性反应,产生与存在的精氨酸酶活性成比例的有色产物。

象形图

Health hazardCorrosion

警示用语:

Danger

危险分类

Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Yuxin Shu et al.
Immunology, 160(4), 345-356 (2020-04-21)
Macrophages are particularly abundant and play an important role throughout the tumor progression process, namely, tumor-associated macrophages (TAM) in the tumor microenvironment. TAM can be polarized to disparate functional phenotypes, the M1 and M2 macrophages. M1-like type macrophages are defined
Andrew F Cumpstey et al.
Nitric oxide : biology and chemistry, 94, 27-35 (2019-10-12)
Native highlanders (e.g. Sherpa) demonstrate remarkable hypoxic tolerance, possibly secondary to higher levels of circulating nitric oxide (NO) and increased microcirculatory blood flow. As part of the Xtreme Alps study (a randomised placebo-controlled trial of dietary nitrate supplementation under field
Monica Vaccari et al.
Frontiers in immunology, 10, 1072-1072 (2019-05-30)
Vaccination with DNA-SIV + ALVAC-SIV + gp120 alum results in inflammasome activation, high levels of IL-1β production, emergency myelopoiesis, and the egress of CXCR4+ CD14+ pre-monocytes from bone marrow. Previously we have shown that this vaccine-induced innate monocyte memory is
Anti-apoptotic role of spermine against lead and/or gamma irradiation-induced hepatotoxicity in male rats.
Rasha A K, et al.
Environmental Science and Pollution Research International, 24(31), 24272-24283 (2017)
Melanoma exosomes promote mixed M1 and M2 macrophage polarization.
Bardi G T, et al.
Cytokine, 105 , 63-72 (2018)

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