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Merck
CN

MAK112

精氨酸酶活性检测试剂盒

sufficient for 200 colorimetric tests

别名:

精氨酸酶检测试剂盒

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关于此项目

NACRES:
NA.84
UNSPSC Code:
12161503

主要文件

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产品名称

精氨酸酶活性检测试剂盒, sufficient for 200 colorimetric tests

usage

sufficient for 200 colorimetric tests

detection method

colorimetric

relevant disease(s)

cancer; immunological diseases; gastrointestinal diseases

storage temp.

−20°C

Gene Information

human ... ARG1(383), ARG2(384)
mouse ... ARG1(11846), ARG2(11847)
rat ... ARG2(29215), Arg1(29221)

相关类别

Application

精氨酸酶活性检测试剂盒用于评估精氨酸酶的活性。
该试剂盒适用于检测酶制备体系、血清、血浆、组织培养物及类似样品中的精氨酸酶活性。还可用于研究药物对精氨酸酶活性的影响。

Biochem/physiol Actions

在该检测中，精氨酸酶可催化精氨酸转化成尿素和鸟氨酸。产生的尿素与底物特异性反应，产生与存在的精氨酸酶活性成比例的有色产物。

Features and Benefits

兼容高通量的操作系统。

General description

精氨酸酶是一种含锰酶，可催化精氨酸转化为尿素和鸟氨酸。大多数哺乳动物体内存在两种同种型精氨酸酶，其组织分布和亚细胞定位有所不同。精氨酸酶I是一种胞质蛋白，主要在肝脏中表达，在肝脏中催化尿素循环的第五步和最后一步。精氨酸酶II是一种线粒体蛋白，组织分布更广，其功能可包括一氧化氮和多胺代谢。精氨酸酶I的活性或表达降低可导致常染色体隐性遗传病高精氨酸血症。血清精氨酸酶活性增加与肝损伤和某些病理状态（如癌症）有关。精氨酸酶还参与免疫系统的多种炎症反应，例如巨噬细胞介导的细胞毒性。

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
112CF06A24
112CF06A24
112CF05A19
112CE06A26
112CE06A19

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Melanoma exosomes promote mixed M1 and M2 macrophage polarization.
Bardi G T, et al.
Cytokine, 105 , 63-72 (2018)
Max Hübner et al.
Critical care medicine, 47(8), e700-e709 (2019-06-01)
Cardiopulmonary bypass is associated with severe immune dysfunctions. Particularly, a cardiopulmonary bypass-related long-lasting immunosuppressive state predisposes patients to a higher risk of postoperative complications, such as persistent bacterial infections. This study was conducted to elucidate mechanisms of post-cardiopulmonary bypass immunosuppression.
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Martina H.
Journal of inherited metabolic disease, 39(3), 331?340-331?340 (2016)
Arginase activity, urea, and hydroxyproline concentration are reduced in keratoconus keratocytes.
Stachon T, et al.
Graefe'S Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(1), 91-97 (2017)
Razieh Tavakoli Oliaee et al.
Microbial pathogenesis, 126, 368-378 (2018-11-07)
Detection of the mechanism of host/parasite interactions in unresponsive forms of anthroponotic cutaneous leishmaniasis (ACL) caused by Leishmania tropica is helpful for immunotherapy and vaccine development. In the present study, the gene expression of toll-like receptors (TLRs), TNF-α, iNOS and
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Product Information Sheet - MAK112

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