产品名称
单胺氧化酶B 人, recombinant, expressed in baculovirus infected BTI insect cells
recombinant
expressed in baculovirus infected BTI insect cells
form
liquid
enzyme activity
≥1 U/mg
packaging
vial of ~2.5 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... MAOB(4129)
Other Notes
犬尿胺的脱氨活性：pH 7.4、37 °C 条件下，一个单位每分钟可脱氨 1 nm 犬尿胺。
General description
单胺氧化酶B是一种线粒体外膜黄素酶，是抗抑郁药和神经保护药的靶点。
Application
单胺氧化酶B已可用于评估年龄对人类大脑的23个不同区域的影响。 它还被用于确定人脑中单胺氧化酶的具体位置。
单胺氧化酶B活性抑制剂被用于治疗各种神经障碍，包括抑郁症。
Biochem/physiol Actions
MAO是线粒体膜的蛋白质。 这些酶可催化内生和外源胺的氧化脱氨反应。 每种亚型具有不同的底物特异性。
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
Dorota Łażewska et al.
Molecules (Basel, Switzerland), 26(12) (2021-07-03)
Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can
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