所有图片(1)
About This Item
经验公式（希尔记法）:
C15H21ClN2O3
CAS号:
分子量:
312.79
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98%
表单
solid
颜色
white to off-white
溶解性
DMSO: >20 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
COc1cc(N)c(Cl)cc1C(=O)OCCN2CCCCC2
InChI
1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3
InChI key
RVFIAQAAZUEPPE-UHFFFAOYSA-N
基因信息
rat ... Htr3a(79246) , Htr4(25324)
生化/生理作用
Potent, selective 5-HT4 serotonin receptor agonist
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
D Yang et al.
Journal of medicinal chemistry, 40(4), 608-621 (1997-02-14)
A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum and the rat esophagus muscle. Monosubstitution
Jean-Louis Soulier et al.
Journal of medicinal chemistry, 48(20), 6220-6228 (2005-09-30)
Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception and the synthesis of bivalent molecules able to influence the dimerization
F De Ponti et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 13(6), 543-553 (2002-03-21)
5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the
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