M7319
ML 10302
≥98%, solid
别名:
2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate
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关于此项目
经验公式（希尔记法）:
C15H21ClN2O3
化学文摘社编号:
分子量:
312.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
产品名称
ML 10302, ≥98%, solid
InChI
1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3
SMILES string
COc1cc(N)c(Cl)cc1C(=O)OCCN2CCCCC2
InChI key
RVFIAQAAZUEPPE-UHFFFAOYSA-N
assay
≥98%
form
solid
color
white to off-white
solubility
DMSO: >20 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Htr3a(79246), Htr4(25324)
Biochem/physiol Actions
Potent, selective 5-HT4 serotonin receptor agonist
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
D Yang et al.
Journal of medicinal chemistry, 40(4), 608-621 (1997-02-14)
A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum and the rat esophagus muscle. Monosubstitution
Jean-Louis Soulier et al.
Journal of medicinal chemistry, 48(20), 6220-6228 (2005-09-30)
Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception and the synthesis of bivalent molecules able to influence the dimerization
F De Ponti et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 13(6), 543-553 (2002-03-21)
5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the
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