生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
9E10, monoclonal
形式
buffered aqueous solution
分子量
62 kDa
种属反应性
human
浓度
~2 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:5000 using c-myc tagged fusion protein
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... MYC(4609)
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一般描述
V-Myc（v-myc禽髓细胞瘤病病毒致癌基因同源物）是一种转录因子，其由MYC基因编码。它最初被描述为禽逆转录病毒致癌基因的同源物。它属于转录因子家族，以碱性区螺旋-环-螺旋/亮氨酸拉链为特征。它与N-Myc和L-Myc一起构成原癌基因家族。它与MAX形成异二聚体，该二聚体与DNA上的E-boxes/CACGTG基序相结合。该基因位于人染色体8q24上。
小鼠抗c-Myc单克隆抗体可识别位于人类致癌基因c-myc产物序列(EQKLISEEDL)内的表位。
免疫原
人p62c-Myc蛋白的合成肽。
应用
小鼠产生的单克隆抗c-Myc抗体适用于免疫沉淀、 免疫印迹、 酶联免疫吸附分析（ELISA）、免疫荧光、 微阵列和电子显微。它也被应用于ChIP（染色质免疫沉淀）。
生化/生理作用
V-myc禽髓细胞瘤病病毒致癌基因同源物属于MYC家族。当这些蛋白过表达时，可导致DNA双链断裂(DSBs)和基因组不稳定。转录因子MYC有助于调节长链非编码RNA(lncRNAs)，后者与癌细胞增殖和肿瘤发生有关。它的过表达也与各种癌症有关，尤其是B细胞淋巴瘤。c-MYC表达的增加对B细胞淋巴瘤向CD4+ T细胞功能表达Ags/肽的能力有负面影响。该蛋白在Ag表达的几个关键点发挥抑制作用。它与Burkitt淋巴瘤和一组弥漫性巨大B细胞淋巴瘤(DLBCL)有关。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
制备说明
工作稀释液：1：5000
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Mirjana Macvanin et al.
Journal of bacteriology, 194(22), 6046-6055 (2012-09-04)
Some unidentified RNA molecules, together with the nucleoid protein HU, were suggested to be involved in the nucleoid structure of Escherichia coli. HU is a conserved protein known for its role in binding to DNA and maintaining negative supercoils in
Željka Škunca et al.
Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 68(3), 299-305 (2015-05-29)
Diffuse large B-cell lymphoma (DLBCL) is classified as lymphoma and various entities using the gene expression of proteins are classified into three groups. The aim of this study was to clarify the clinical, biological, immunophenotypic and cytogenetic features of DLBCL
Susanna Ambrosio et al.
Mutation research, 774, 6-13 (2015-03-17)
Although it is established that when overexpressed, the MYC family proteins can cause DNA double-stand breaks (DSBs) and genome instability, the mechanisms involved remain unclear. MYC induced genetic instability may result from increased DNA damage and/or reduced DNA repair. Here
Taewan Kim et al.
Journal of the National Cancer Institute, 107(4), doi:10-doi:10 (2015-02-11)
The functions of long noncoding RNAs (lncRNAs) have been identified in several cancers, but the roles of lncRNAs in colorectal cancer (CRC) are less well understood. The transcription factor MYC is known to regulate lncRNAs and has been implicated in
Marta G Del Barrio et al.
Development (Cambridge, England), 134(19), 3427-3436 (2007-08-31)
In the developing central nervous system, cellular diversity depends in part on organising signals that establish regionally restricted progenitor domains, each of which produces distinct types of differentiated neurons. However, the mechanisms of neuronal subtype specification within each progenitor domain
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