M4145
米诺地尔
≥99% (TLC), powder, potassium channel activator
别名:
6-（1-哌啶基）-2,4-嘧啶二胺 3-氧化物, 6-（1-哌啶基）嘧啶-2,4-二胺 3-氧化物
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关于此项目
经验公式（希尔记法）:
C9H15N5O
化学文摘社编号:
分子量:
209.25
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
米诺地尔, ≥99% (TLC)
质量水平
方案
≥99% (TLC)
mp
272-274 °C (dec.) (lit.)
创始人
Johnson & Johnson
SMILES字符串
NC1=CC(=NC(=N)N1O)N2CCCCC2
InChI
1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChI key
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
基因信息
human ... KCNJ1(3758)
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相关类别
应用
米诺地尔作为测试药物：
- 应用于真皮乳头球体模型中，旨在研究头发再生效果
- 口服给大鼠，识别药物诱导血管损失的生物标志物
- 口服灌胃非人灵长类动物模型，研究其对倾斜反应的效果
生化/生理作用
激活 ATP 激活的 K+ 通道；血管扩张剂；减缓或停止脱发，促进头发再生。
米诺地尔最初用于治疗高血压，也会诱发多毛症。它被视为是治疗雄激素性脱发的有效药物。
特点和优势
该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Ilaria Aurigemma et al.
Biochemical and biophysical research communications, 720, 150104-150104 (2024-05-16)
The T-BOX transcription factor TBX1 is essential for the development of the pharyngeal apparatus and it is haploinsufficient in DiGeorge syndrome (DGS), a developmental anomaly associated with congenital heart disease and other abnormalities. The murine model recapitulates the heart phenotype
J I Kourie
The Journal of membrane biology, 164(1), 47-58 (1998-06-24)
The lipid bilayer technique was used to examine the effects of the ATP-sensitive K+ channel inhibitor (glibenclamide) and openers (diazoxide, minoxidil and cromakalim) and Cl- channel activators (GABA and diazepam) on two types of chloride channels in the sarcoplasmic reticulum
A non-human primate model for investigating drug-induced risk of orthostatic hypotension and sympathetic dysfunction: Preclinical correlate to a clinical test
Bhatt S, et al.
Journal of Pharmacological and Toxicological Methods, 73(2), 49-55 (2015)
Stefan Sarkovich et al.
Journal of experimental orthopaedics, 10(1), 84-84 (2023-08-22)
Synovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following arthroplasty. To supplement joint conditioning aimed at maximizing peri-operative function, we evaluated the antifibrotic effect of Minoxidil (MXD) on formation of pyridinoline
Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Gupta AC, et al.
Journal of Cellular Physiology, 233(11), 9015-9030 (2018)
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