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产品名称
米诺地尔, ≥99% (TLC)
质量水平
方案
≥99% (TLC)
mp
272-274 °C (dec.) (lit.)
创始人
Johnson & Johnson
SMILES字符串
NC1=CC(=NC(=N)N1O)N2CCCCC2
InChI
1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChI key
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
基因信息
human ... KCNJ1(3758)
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应用
米诺地尔作为测试药物：
- 应用于真皮乳头球体模型中，旨在研究头发再生效果
- 口服给大鼠，识别药物诱导血管损失的生物标志物
- 口服灌胃非人灵长类动物模型，研究其对倾斜反应的效果
生化/生理作用
激活 ATP 激活的 K+ 通道；血管扩张剂；减缓或停止脱发，促进头发再生。
米诺地尔最初用于治疗高血压，也会诱发多毛症。它被视为是治疗雄激素性脱发的有效药物。
特点和优势
该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
J van der Velden et al.
Cellular and molecular life sciences : CMLS, 55(5), 788-798 (1999-06-24)
To investigate whether during cardiac hypertrophy changes occur in contractile protein composition and in mechanical and energetic properties of the myocardium, contractile protein composition, isometric force and adenosine triphosphate (ATP) consumption were studied in control and hypertrophied guinea-pig hearts. Cardiac
C Löffler-Walz et al.
British journal of pharmacology, 123(7), 1395-1402 (1998-05-14)
1. The binding of [3H]-P1075, a potent opener of adenosine-5'-triphosphate-(ATP)-sensitive K+ channels, was studied in a crude heart membrane preparation of the rat, at 37 degrees C. 2. Binding required MgATP. In the presence of an ATP-regenerating system, MgATP supported
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