质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
off-white to light brown
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC
InChI
1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
InChI key
HXTGXYRHXAGCFP-OAQYLSRUSA-N
基因信息
human ... HTR2A(3356)
一般描述
M100907 可阻断血清素 2A (5-HT2A) 受体并产生抗抑郁作用。它可用于治疗多巴胺能异常。
生化/生理作用
M100907 是一种选择性 5-HT2A 拮抗剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Kathryn A Cunningham et al.
ACS chemical neuroscience, 4(1), 110-121 (2013-01-22)
Relapse to cocaine dependence, even after extended abstinence, involves a number of liability factors including impulsivity (predisposition toward rapid, unplanned reactions to stimuli without regard to negative consequences) and cue reactivity (sensitivity to cues associated with cocaine-taking which can promote
The selective 5-HT 2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine
Marek GJ, et al.
Neuropsychopharmacology, 30(12), 2205-2205 (2005)
Paul J Fletcher et al.
Neuropharmacology, 62(7), 2288-2298 (2012-02-22)
The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT(2A) and 5-HT(2C) receptors, modulates dopamine function. In these experiments we examined the effects of the 5-HT(2C) receptor agonist Ro60-0175 and the 5-HT(2A) receptor
Ragy R Girgis et al.
Psychiatry research, 194(3), 230-234 (2011-11-15)
Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [(11)C]MDL 100907 and [(11)C]DASB to characterize the 5-HT(2A) receptor and serotonin
Angela J Rylands et al.
Biological psychiatry, 72(12), 1004-1011 (2012-07-28)
Impulsive aggression (IA) in adults is associated with brain serotonin (5-HT) system abnormalities and is more common following childhood adversity. Within aggressive behavior, IA and callous unemotional (CU) traits are core components of differentiable factors with opposing 5-HT abnormalities. We
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