M3324
M100907
≥98% (HPLC), 5-HT2A Antagonist, powder
别名:
(R)-(+)-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基]-4-吡啶甲醇, MDL100907, 诺和灵
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关于此项目
经验公式（希尔记法）:
C22H28FNO3
化学文摘社编号:
分子量:
373.46
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
M100907, ≥98% (HPLC)
SMILES string
COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC
InChI key
HXTGXYRHXAGCFP-OAQYLSRUSA-N
InChI
1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
assay
≥98% (HPLC)
form
powder
color
off-white to light brown
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... HTR2A(3356)
相关类别
General description
M100907 可阻断血清素 2A (5-HT2A) 受体并产生抗抑郁作用。它可用于治疗多巴胺能异常。
Biochem/physiol Actions
M100907 是一种选择性 5-HT2A 拮抗剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Paul J Fletcher et al.
Neuropharmacology, 62(7), 2288-2298 (2012-02-22)
The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT(2A) and 5-HT(2C) receptors, modulates dopamine function. In these experiments we examined the effects of the 5-HT(2C) receptor agonist Ro60-0175 and the 5-HT(2A) receptor
Kathryn A Cunningham et al.
ACS chemical neuroscience, 4(1), 110-121 (2013-01-22)
Relapse to cocaine dependence, even after extended abstinence, involves a number of liability factors including impulsivity (predisposition toward rapid, unplanned reactions to stimuli without regard to negative consequences) and cue reactivity (sensitivity to cues associated with cocaine-taking which can promote
The selective 5-HT 2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine
Marek GJ, et al.
Neuropsychopharmacology, 30(12), 2205-2205 (2005)
Ragy R Girgis et al.
Psychiatry research, 194(3), 230-234 (2011-11-15)
Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [(11)C]MDL 100907 and [(11)C]DASB to characterize the 5-HT(2A) receptor and serotonin
Peter S Talbot et al.
NeuroImage, 59(1), 271-285 (2011-07-26)
Scanning properties and analytic methodology of the 5-HT2A receptor-selective positron emission tomography (PET) tracer 11C-MDL100907 have been partially characterised in previous reports. We present an extended characterisation in healthy human subjects. 64 11C-MDL100907 PET scans with metabolite-corrected arterial input function
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