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质量水平
方案
≥95% (HPLC)
mp
192 °C (dec.) (lit.)
溶解性
DMSO: ≥20 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1
InChI
1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H
InChI key
OOVDEPZODSXAMU-UHFFFAOYSA-N
基因信息
human ... TH(7054)
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应用
α-甲基-DL-酪氨酸甲酯盐酸盐已被用于评估去甲肾上腺素的转换。
生化/生理作用
α-甲基-DL-酪氨酸（α-MT）可防止过度活性、嗅舔啃综合征、厌食症并改善苯丙胺的某些作用。它可抑制多巴胺的产生并防止突变体α-突触核蛋白刺激的细胞凋亡。
酪氨酸羟化酶抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Antiamphetamine effects following inhibition of tyrosine hydroxylase
Weissman A
Journal of Pharmacology and Experimental Therapeutics, 151(3), 339-352 (1966)
Central sympathetic innervations to visceral and subcutaneous white adipose tissue
Nguyen, Ngoc Ly T and Randall, Jessica and Banfield, Bruce W and Bartness, Timoth NLT, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 306(6), R375-R386 (2014)
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
Xu J, et al.
Nature Medicine, 8(6), 600-600 (2002)
J J Liaw et al.
Brain research. Molecular brain research, 13(3), 231-238 (1992-04-01)
Temporal changes in tyrosine hydroxylase (TH) mRNA levels in medullary A1 and A2 neurons and locus coeruleus (LC) cells were studied 6, 12 and 24 h following orchidectomy in rats. Brains from intact controls and sham castrated rats also were
E Sundström et al.
Brain research, 528(2), 181-188 (1990-10-01)
The long-term effect of the parkinsonism inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on pre- and postsynaptic structures of the nigrostriatal and mesolimbic dopamine (DA) system in adult C57BL/6 mice (2 x 40 mg/kg s.c.) was investigated using neurochemical and behavioral methods. It
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