推荐产品
质量水平
检测方案
≥98%
形式
solid
溶解性
ethanol: 10 mg/mL
SMILES字符串
O=C1C(N=C(COC)N2)=C2N(CC(C)C)C(N1C)=O
InChI
1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
InChI key
NBLBCGUCPBXKOV-UHFFFAOYSA-N
基因信息
human ... PDE1A(5136) , PDE1B(5153)
生化/生理作用
Selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase I (PDE1).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Wenkuan Xin et al.
American journal of physiology. Renal physiology, 310(10), F994-F999 (2016-02-26)
Large-conductance Ca(2+)-activated K(+) (BK) channels are critical regulators of detrusor smooth muscle (DSM) function. We aimed to investigate phosphodiesterase type 1 (PDE1) interactions with BK channels in human DSM to determine the mechanism by which PDE1 regulates human urinary bladder
Methylxanthine inhibitors of phosphodiesterases.
J N Wells et al.
Methods in enzymology, 159, 489-496 (1988-01-01)
Haruka Kogiso et al.
International journal of molecular sciences, 21(6) (2020-03-18)
In Ts1Rhr, a Down syndrome model mouse, the airway ciliary beatings are impaired; that is, decreases in ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of ciliary beat amplitude)). A resumption to two copies of the Pcp4
Haruka Kogiso et al.
International journal of molecular sciences, 19(3) (2018-03-03)
Sei-hai-to (TJ-90, Qing Fei Tang), a Chinese traditional medicine, increases ciliary beat frequency (CBF) and ciliary bend angle (CBA) mediated via cAMP (3',5'-cyclic adenosine monophosphate) accumulation modulated by Ca2+-activated phosphodiesterase 1 (PDE1A). A high concentration of TJ-90 (≥40 μg/mL) induced
H S Ahn et al.
Biochemical pharmacology, 38(19), 3331-3339 (1989-10-01)
In this study three forms of cyclic nucleotide phosphodiesterase (PDE) isolated from rabbit aorta were pharmacologically characterized, and the consequence of selective inhibition of calmodulin-stimulated PDE (CaM-PDE) and cGMP specific PDE (cG-PDE) was evaluated using PDE inhibitors. The cG-PDE (F1)
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