M217
Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat
clone mAb 35, purified immunoglobulin, buffered aqueous solution
别名:
Anti-ACHR
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关于此项目
Conjugate:
unconjugated
Clone:
mAb 35, monoclonal
Application:
immunohistochemistry (frozen sections)
Species reactivity:
human, chicken, eel
Citations:
1
Technique(s):
immunohistochemistry (frozen sections): 1:3,000
Uniprot accession no.:
产品名称
Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat, clone mAb 35, purified immunoglobulin, buffered aqueous solution
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
mAb 35, monoclonal
form
buffered aqueous solution
species reactivity
human, chicken, eel
should not react with
Xenopus
technique(s)
immunohistochemistry (frozen sections): 1:3,000
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHRNA1(1134), CHRNA3(1136), CHRNA5(1138)
Biochem/physiol Actions
Binds to the main immunogenic region on the extracellular surface of the α1 subunit of muscle AChR′s and to homologous regions on α3 and α5 subunits of neuronal AChR′s. The epitope is located on the extracellular surface of the α1 subunit of the muscle nicotinic acetylcholine receptor. The antibody binds to denatured chick α5 AChR, but does not bind well to denatured α3, α4, α7, α8, and β2. It may also bind β3 due to homology of main immunogenic region. May be used to localize and detect the α1, α3 and α5 subunits of the nicotinic acetylcholine receptor (AChR).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
nicotinic acetylcholine receptor from the electric eel Electrophorus.
Legal Information
Sold with permission of the Salk Institute
Physical form
Solution in 20 mM Na3PO4, pH 7.2, containing 150 mM NaCl and 0.05 % sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Jee-Young Park et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10211-10218 (2014-08-01)
Mutations in AChR subunits, expressed as pentamers in neuromuscular junctions (NMJs), cause various types of congenital myasthenic syndromes. In AChR pentamers, the adult ε subunit gradually replaces the embryonic γ subunit as the animal develops. Because of this switch in
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