M1946
Anti-Monoamine Oxidase B (C-terminal) 兔抗
affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution
别名:
Anti-Adrenalin oxidase, Anti-MAO, brain, Anti-MAO, platelet, Anti-Tyramine oxidase
产品名称
Anti-Monoamine Oxidase B (C-terminal) 兔抗, affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution
Quality Level
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~58 kDa
species reactivity
rat, mouse, human
packaging
antibody small pack of 25 μL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
western blot: 0.25-0.5 μg/mL using rat liver mitochondrial fraction and HEK-293T cells expressing human MAO-B
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ASCC3(10973), MAOB(4129)
rat ... Maob(25750)
相关类别
Application
Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Anti-Monoamine Oxidase B (C-terminal) specifically recognizes human, mouse and rat MAO-B.
Monoamine oxidases (MAOs) are the main degradative enzymes responsible for the oxidative deamination of biogenic amines, such as epinephrine, norepinephrine, serotonin (5-HT) and dopamine in the central nervous system (CNS) and peripheral tissues. MAO-B is considered the predominant isoform responsible for dopamine metabolism in the human CNS. It participates in the metabolism of neuroactive and vasoactive amines. MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-Monoamine Oxidase B (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human monoamine oxidase B (MAO-B) conjugated to KLH. Monoamine oxidases (MAOs) are mitochondrial flavoprotein enzymes, localized to the mitochondrial outer membrane. MAO-B is mainly found in the brain in dopaminergic, serotonergic and histaminergic neurons, as well as in astrocytes. It is a member of the flavin monoamine oxidase family. MAOB gene is mapped to human chromosome Xp11.
Physical form
Supplied as a solution in 0.01 M PBS, pH 7.4, containing 15 mM sodium azide as a preservative.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology
Mallajosyula JK, et al.
PLoS ONE, 3(2), e1616-e1616 (2008)
PET imaging for addiction medicine: From neural mechanisms to clinical considerations
Wiers CE, et al.
Progress in Brain Research, 224, 175-201 (2016)
Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine Oxidases
Edmondson DE, et al.
Biochemistry, 48(20), 4220-4220 (2009)
A linkage study of schizophrenia to markers within Xp11 near the MAOB gene
Dann J, et al.
Psychiatry Research, 70(3), 131-143 (1997)
Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia
Sun J, et al.
Psychiatry Research, 198(2), 202-206 (2012)
相关内容
Instructions
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