所有图片(1)
About This Item
经验公式（希尔记法）:
C7H15NO4
CAS号:
分子量:
177.20
Beilstein:
1524564
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.32
生物来源
synthetic (organic)
质量水平
检测方案
≥98%
形式
powder
溶解性
methanol: 10 mg/mL, clear, colorless
抗生素抗菌谱
viruses
作用机制
enzyme | inhibits
储存温度
−20°C
SMILES字符串
CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
InChI key
AAKDPDFZMNYDLR-XZBKPIIZSA-N
基因信息
mouse ... Gaa(14387) , Glb1(12091) , Treh(58866)
rat ... Man2a1(25478) , Si(497756)
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一般描述
Chemical structure: glucosamine
生化/生理作用
Interferes with metabolism of N-linked glycoproteins by inhibition of glucosidase.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Diego A Caraballo et al.
G3 (Bethesda, Md.), 10(2), 755-768 (2019-12-05)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences
N Y Marcus et al.
The Journal of biological chemistry, 275(3), 1987-1992 (2000-01-15)
It is now well known that the addition and trimming of oligosaccharide side chains during post-translational modification play an important role in determining the fate of secretory, membrane, and lysosomal glycoproteins. Recent studies have suggested that trimming of oligosaccharide side
E D Faber et al.
Pharmaceutical research, 9(11), 1442-1450 (1992-11-01)
We studied the pharmacokinetics of two synthetic derivatives of 1-deoxynojirimycin in the rat after intravenous administration. The mannosidase IA/B inhibitor 1-deoxymannojirimycin and the glucosidase inhibitor N-methyl-1-deoxynojirimycin exhibited minimal plasma protein binding and showed a rapid biphasic plasma disappearance, with an
K Murakami et al.
Journal of bacteriology, 176(9), 2635-2639 (1994-05-01)
A Mucor pusillus mutant defective in asparagine-linked glycosylation was found in our stock cultures. This mutant, designated 1116, secreted aspartic proteinase (MPP) in a less-glycosylated form than that secreted by the wild-type strain. Analysis of enzyme susceptibility, lectin binding, and
J C Ridruejo et al.
Biochimica et biophysica acta, 993(2-3), 179-185 (1989-12-08)
Castanospermine, 1-deoxynojirimycin, and N-methyl-1-deoxynojirimycin, three well-characterized inhibitors of the glucosidases involved in the processing of N-linked oligosaccharides, did not affect the biosynthesis or the secretion of exoglucanases (EC 3.2.1.58) from Saccharomyces cerevisiae and Candida albicans but inhibited the activity itself.
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