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Merck
CN

M1777

Sigma-Aldrich

N-Methyl-1-deoxynojirimycin

≥98%

别名:

1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol

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About This Item

经验公式(希尔记法):
C7H15NO4
CAS号:
分子量:
177.20
Beilstein:
1524564
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.32

生物来源

synthetic (organic)

质量水平

方案

≥98%

表单

powder

溶解性

methanol: 10 mg/mL, clear, colorless

抗生素抗菌谱

viruses

作用机制

enzyme | inhibits

储存温度

−20°C

SMILES字符串

CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

InChI

1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1

InChI key

AAKDPDFZMNYDLR-XZBKPIIZSA-N

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一般描述

Chemical structure: glucosamine

生化/生理作用

Interferes with metabolism of N-linked glycoproteins by inhibition of glucosidase.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Diego A Caraballo et al.
G3 (Bethesda, Md.), 10(2), 755-768 (2019-12-05)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences
G C Trudel et al.
Biochemical and biophysical research communications, 184(1), 125-130 (1992-04-15)
The glycoprotein processing inhibitors bromoconduritol and N-methyl-1-deoxynojirimycin inhibit myoblast fusion and differentiation, suggesting the critical involvement of one or more glycoproteins in the control of skeletal myogenesis. In the present study we have examined the effect of inhibitors of glycoprotein
E D Faber et al.
Pharmaceutical research, 11(1), 144-150 (1994-01-01)
The hepatic disposition of two glycosidase inhibitors was studied in the isolated perfused rat liver and after subcellular fractionation. The mannosidase inhibitor 1-deoxymannojirimycin (dMM) and the glucosidase inhibitor N-methyl-1-deoxynojirimycin (MedNM) exhibited minimal binding to albumin and reached liver concentrations that
A J Verhoeven et al.
Journal of lipid research, 31(10), 1883-1893 (1990-10-01)
Rat hepatic lipase is a glycoprotein bearing two N-linked oligosaccharide chains. The importance of glycosylation in the secretion of hepatic lipase was studied using freshly isolated rat hepatocytes. Various inhibitors of oligosaccharide synthesis and processing were used at concentrations that
M Arai et al.
British journal of pharmacology, 133(5), 635-642 (2001-06-29)
Preischaemic treatment with N-methyl-1-deoxynojirimycin (MOR-14), an alpha-1,6-glucosidase inhibitor, attenuates glycogenolysis and lactate accumulation during ischaemia and markedly reduces infarct size in rabbit hearts. In the present study, we have investigated whether protein kinase C (PKC), a principal mediator of ischaemic

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