M1523
蝇蕈醇
≥98% (TLC), powder, GABAA receptor agonist.
别名:
3-羟基-5-氨甲基-异噁唑, 5-氨甲基-3-异噁唑醇, 5-氨甲基-3-羟基-异噁唑, Pantherine, 毒蝇蕈醇
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选择尺寸
关于此项目
经验公式（希尔记法）:
C4H6N2O2
化学文摘社编号:
分子量:
114.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
220-430-4
MDL number:
Beilstein/REAXYS Number:
1618960
产品名称
蝇蕈醇, powder
InChI key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
SMILES string
NCC1=CC(=O)NO1
form
powder
color
white to off-white
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Gabra2(29706)
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Application
蝇蕈醇已用于：
- 降低外侧杏仁核(LA)中条件性恐惧表达
- 消除雪貂的皮层细胞反应
- 灭活斑胸草雀中的巢皮层外侧巨细胞核(LMAN)
Biochem/physiol Actions
GABAA受体激动剂。
Features and Benefits
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
General description
蝇蕈醇(Muscimol)是一种异噁唑类精神性物质，主要存在于毒蝇伞(Amanita muscaria)等菇类中。可降低大脑糖代谢，提高脑中的5-羟色胺浓度。蝇蕈醇具有致幻作用。与感知曲解、恶心和呕吐有关联。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Relation of cortical cell orientation selectivity to alignment of receptive fields of the geniculocortical afferents that arborize within a single orientation column in ferret visual cortex
Chapman B, et al.
The Journal of Neuroscience, 11(5), 1347-1358 (1991)
Muscimol as an ionotropic GABA receptor agonist
Johnston GAR
Neurochemical Research, 39(10), 1942-1947 (2014)
The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement
Erlich JC, et al.
Frontiers in Behavioral Neuroscience, 6, 16-16 (2012)
Julen Hernandez-Lallement et al.
Current biology : CB, 30(6), 949-961 (2020-03-07)
Empathy, the ability to share another individual's emotional state and/or experience, has been suggested to be a source of prosocial motivation by attributing negative value to actions that harm others. The neural underpinnings and evolution of such harm aversion remain
Su-Hyuk Ko et al.
International journal of molecular sciences, 21(22) (2020-11-19)
Autophagy is a conserved pathway that plays a key role in cell homeostasis in normal settings, as well as abnormal and stress conditions. Autophagy dysfunction is found in various neurodegenerative diseases, although it remains unclear whether autophagy impairment is a
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DISCOVER Bioactive Small Molecules for Neuroscience
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