M149
甲硫替平 甲磺酸盐
≥98% (HPLC), solid
别名:
1-[10，11-二氢-8-（甲硫基）二苯并[b，f]硫平-10-基]-4-甲基哌嗪 甲磺酸盐, 甲替平 甲磺酸盐
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关于此项目
线性分子式:
C20H24N2S2 · CH3SO3H
化学文摘社编号:
分子量:
452.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
甲硫替平 甲磺酸盐, ≥98% (HPLC), solid
InChI key
CZMDZGZYKOGLJY-UHFFFAOYSA-N
SMILES string
CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1
InChI
1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: 13 mg/mL
Quality Level
Gene Information
human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR6(3362), HTR7(3363)
Application
甲硫替平甲磺酸盐已用于探索循环细胞与生态位之间的关系。它也已用于5-羟色胺（5-HT）和拮抗剂体内生物测定以及体内拮抗剂和脂多糖刺激。
Biochem/physiol Actions
甲硫替平甲磺酸盐是一种5-HT1、5-HT6、5-HT75-羟色胺受体拮抗剂，可阻断5-羟色胺自身受体。
General description
甲硫替平属于一类新的二苯并噻吩。甲硫替平具有精神抑制活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
C Grånäs et al.
European journal of pharmacology, 380(2-3), 171-181 (1999-10-08)
Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding studies
Yuan Lai et al.
Neurobiology of learning and memory, 173, 107278-107278 (2020-07-12)
Conditioned taste aversion (CTA) learning induces the devaluation of a preferred food through its pairing with a stimulus inducing internal illness. In invertebrates, it is still unclear how this aversive learning impairs the memories of stimuli that had been associated
P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
T Nilsson et al.
European journal of pharmacology, 372(1), 49-56 (1999-06-22)
5-Hydroxytryptamine (5-HT) can produce both vasoconstrictor and vasorelaxant effects in human coronary arteries and the response to 5-HT can be influenced by the presence of disease. The aim of the present study was to elucidate the 5-HT receptor subtypes responsible
F G Boess et al.
Molecular pharmacology, 54(3), 577-583 (1998-09-09)
Ro 63-0563 [4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulfonamide] is a high affinity 5-hydroxytryptamine6 (HT6) receptor antagonist with more than 100-fold selectivity for the 5-HT6 receptor compared with 69 other receptors and binding sites. The present study describes the properties of [3H]Ro 63-0563, the
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