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质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white
溶解性
H2O: 13 mg/mL
SMILES字符串
CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1
InChI
1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)
InChI key
CZMDZGZYKOGLJY-UHFFFAOYSA-N
基因信息
human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR6(3362) , HTR7(3363)
一般描述
甲硫替平属于一类新的二苯并噻吩。甲硫替平具有精神抑制活性。
应用
甲硫替平甲磺酸盐已用于探索循环细胞与生态位之间的关系。它也已用于5-羟色胺（5-HT）和拮抗剂体内生物测定以及体内拮抗剂和脂多糖刺激。
生化/生理作用
甲硫替平甲磺酸盐是一种5-HT1、5-HT6、5-HT75-羟色胺受体拮抗剂，可阻断5-羟色胺自身受体。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Yuan Lai et al.
Neurobiology of learning and memory, 173, 107278-107278 (2020-07-12)
Conditioned taste aversion (CTA) learning induces the devaluation of a preferred food through its pairing with a stimulus inducing internal illness. In invertebrates, it is still unclear how this aversive learning impairs the memories of stimuli that had been associated
P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
C Grånäs et al.
European journal of pharmacology, 380(2-3), 171-181 (1999-10-08)
Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding studies
T Nilsson et al.
European journal of pharmacology, 372(1), 49-56 (1999-06-22)
5-Hydroxytryptamine (5-HT) can produce both vasoconstrictor and vasorelaxant effects in human coronary arteries and the response to 5-HT can be influenced by the presence of disease. The aim of the present study was to elucidate the 5-HT receptor subtypes responsible
F G Boess et al.
Molecular pharmacology, 54(3), 577-583 (1998-09-09)
Ro 63-0563 [4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulfonamide] is a high affinity 5-hydroxytryptamine6 (HT6) receptor antagonist with more than 100-fold selectivity for the 5-HT6 receptor compared with 69 other receptors and binding sites. The present study describes the properties of [3H]Ro 63-0563, the
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