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Merck
CN

M0267

(+/-)-美沙酮 盐酸盐

powder, ≥98%

别名:

6-Dimethylamino-4,4-diphenylheptan-3-one hydrochloride

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关于此项目

经验公式（希尔记法）:
C21H27NO · HCl
化学文摘社编号:
1095-90-5
分子量:
345.91
NACRES:
NA.77
PubChem Substance ID:
24896546
UNSPSC Code:
12352200
EC Number:
214-140-7
MDL number:
MFCD00058014

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InChI key

FJQXCDYVZAHXNS-UHFFFAOYSA-N

InChI

1S/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H

SMILES string

Cl.CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2

assay

≥98%

form

powder

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal), kontrollierte Droge in Deutschland

Quality Level

200

Gene Information

human ... OPRM1(4988)

color

white to off-white

solubility

H2O: 50 mg/mL, clear, colorless to yellow

originator

Novartis

相关类别

Biochem/physiol Actions

μ opioid receptor agonist that desensitizes both the μ opioid receptor and the δ opioid receptor on chronic exposure; narcotic analgesic, characterized by a gradual onset of action and prolonged, milder withdrawal; may also block L-type calcium channels independently of its effects on opioid receptors.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300,H336

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

target_organs

Central nervous system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000495812
0000495812
0000473444
0000473443
0000473443

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A D Blake et al.
The Journal of biological chemistry, 272(2), 782-790 (1997-01-10)
Mu opioid receptors mediate the analgesia induced by morphine. Prolonged use of morphine causes tolerance development and dependence. To investigate the molecular basis of tolerance and dependence, the cloned mouse mu opioid receptor with an amino-terminal epitope tag was stably
Olivier René et al.
Nucleic acids research, 39(5), 1855-1867 (2010-11-10)
The late stages of 30S and 50S ribosomal subunits biogenesis have been studied in a wild-type (wt) strain of Escherichia coli (MC4100) subjected to a severe heat stress (45-46°C). The 32S and 45S ribosomal particles (precursors to 50S subunits) and
Y Yu et al.
The Journal of biological chemistry, 272(46), 28869-28874 (1997-11-20)
Mu opioid receptors are subject to phosphorylation and desensitization through actions of at least two distinct biochemical pathways: agonist-dependent mu receptor phosphorylation and desensitization induced by a biochemically distinct second pathway dependent on protein kinase C activation (1). To better
S Shadnia et al.
Clinical toxicology (Philadelphia, Pa.), 51(8), 777-782 (2013-08-27)
Due to an increase in the number of methadone maintenance clinics in the past decade in Iran, acute methadone overdose has become one of the common poisonings in our society. To compare the characteristics of methadone poisoning between syrup and
Laura McGlone et al.
The British journal of ophthalmology, 98(2), 238-245 (2013-11-20)
Flash visual evoked potentials (VEPs) were abnormal in a cohort of 100 neonates exposed to maintenance methadone in utero. This prospective cohort study now describes clinical visual and electrophysiological outcomes at 6 months. Visual assessment included modified Atkinson test battery;
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