product name
LY-294,002 盐酸盐, solid, ≥98% (HPLC)
生物来源
microbial (Staphylococcus roseus)
质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
white to off-white
溶解性
DMSO: >5 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI key
CZQHHVNHHHRRDU-UHFFFAOYSA-N
一般描述
应用
- 人肺癌细胞中的磷酸肌醇3-激酶（PI3K）
- 间充质干细胞（MSCs）的自噬。
- 成纤维细胞 心肌细胞中的丝氨酸/苏氨酸特异性蛋白激酶（AKT）信号传导。
生化/生理作用
特点和优势
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the solution stability in DMSO for Product L9908, LY-294,002 hydrochloride?
After reconstitution in DMSO, aliquot and freeze the stock solution at -20 °C. DMSO stock solutions are stable for at least 1 month at -20 °C.
What is the recommended concentration for using Product L9908, LY-294,002 hydrochloride?
One can use this product at 50 uM concentration.
Can I use Product L9908, LY-294,002 hydrochloride, in conjugation with Wortmannin?
Sigma-Aldrich has not done any such testing, but the following references may be helpful: Phosphatidylinositol 3´-Kinase Is a Critical Mediator of Interferon-γ-Induced Increases in Enteric Epithelial Permeability E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils Activation of Phosphoinositide 3´-kinase in Response to High Glucose Leads to Regulation of Reactive Oxygen Species Related Nuclear Factor-κB Activation and Cyclooxygenase-2 Expression in Mesangial Cells
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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