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生物来源
Pseudomonas aeruginosa (10)
质量水平
形式
lyophilized powder
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to faint yellow
溶解性
water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
运输
ambient
储存温度
2-8°C
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一般描述
本品是从铜绿假单胞菌（Pseudomonas aeruginosa ）血清型10.22中提取得到的苯酚。来源菌株为ATCC 27316。
应用
脂多糖 (LPS) 是革兰氏阴性菌细胞壁的特征性成分。LPS 及其脂质 A 部分通过 Toll 样受体 4 (TLR4) 刺激先天免疫系统的细胞，TLR4 是 Toll 样受体蛋白家族的成员之一，可识别常见的病原体相关分子模式 (PAMP)。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的破坏。
制备说明
本品溶于水(5 mg/ml)或细胞培养基（1 mg/ml），得到浑浊的淡黄色溶液。以盐水为溶剂时，经过涡旋并加热至70-80 oC后，得到浓度更高但仍然浑浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中，可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液，而以水为溶剂将得到均匀的混浊溶液。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
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