L9133
亮氨酸脑啡肽 乙酸盐 水合物
≥95% (HPLC), μ- and δ-opioid receptor agonist
别名:
亮氨酸脑啡肽
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关于此项目
经验公式（希尔记法）:
C28H37N5O7 · xC2H4O2 · yH2O
分子量:
555.62 (anhydrous free base basis)
UNSPSC Code:
12352209
eCl@ss:
32160409
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
亮氨酸脑啡肽 乙酸盐 水合物, ≥95% (HPLC)
SMILES string
O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
InChI
1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
InChI key
QKDIOZBQOQJXFR-XQCXOTTHSA-N
assay
≥95% (HPLC)
storage temp.
−20°C
Quality Level
Gene Information
human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)
Application
亮氨酸脑啡肽乙酸盐盐水合物已用于单级 TOF 模式下 Q-Tof Micro 混合，三重四极杆正交飞行时间（TOF）质谱仪的校准。它也已用于进行质谱的校准。它也已被用于液相色谱-质谱（LCMS）/ MS 中进行系统校准和光谱的相对校正。
Biochem/physiol Actions
亮氨酸脑啡肽（LEU-ENK）在 μ-和 δ-阿片受体位点均起激动剂的作用。它也可能在吗啡敏感的突触中充当神经递质。亮氨酸脑啡肽还与疼痛调节有关。骆驼泪神经中表达的 LEU-ENK 调节泪液和蛋白质分泌。LEU-ENK 在代谢过程中会被多种酶降解，包括氨基肽酶 N（APN）、中性内肽酶（NEP）、二肽基肽酶 3（DPP3）、羧基肽酶 A6（CPA-6）和血管紧张素转换酶（ACE），有时也称为脑啡肽酶。
General description
亮氨酸脑啡肽是一种五肽，是中央和周围组织的正常成分。亮氨酸脑啡肽的氨基酸序列为 Tyr-Gly-Gly-Phe-Leu，分布在包括人在内的多种动物的大脑中。它是一种内源性阿片类神经递质/神经调节剂，位于大脑中和δ受体类似的位置。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
OPIORPHIN AS ENDOGENOUS PEPTIDE OF HUMAN SALIVA ACTS
AS INHIBITOR OF PROTEASE ENZYMES OF ENKEPHALINS
AS INHIBITOR OF PROTEASE ENZYMES OF ENKEPHALINS
Sarker k and Jyoti Sen D
World Journal of Pharmaceutical Research, 6, 1727-1733 (2017)
A P Sayani et al.
Journal of pharmaceutical sciences, 82(11), 1179-1185 (1993-11-01)
Leucine enkephalin (Tyr-Gly-Gly-Phe-Leu; Leu-Enk) is a naturally occurring peptide that has been shown to have pain modulating properties. To evaluate the feasibility of using various absorptive mucosae as a route of systemic delivery, the stability of Leu-Enk and the effect
F Bolacchi et al.
Neurochemical research, 21(8), 875-884 (1996-08-01)
The hydrolysis of leucine enkephalin by the proteolytic enzymes present in human and rabbit plasma has been studied by kinetic and chromatographic techniques. Data obtained indicate the existence of noticeable intraspecific differences in the kinetics of leu-enkephalin degradation, and of
J Hughes et al.
Nature, 258(5536), 577-580 (1975-12-18)
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by
Pattern of distribution of neuropeptides in the camel lacrimal gland.
Adeghate E
Neuropeptides, 30(6), 566-571 (1996)
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