跳转至内容
Merck
CN
所有图片(2)

主要文件

查看所有文档

安全信息

L9133

Sigma-Aldrich

亮氨酸脑啡肽 乙酸盐 水合物

≥95% (HPLC)

别名:

Leucine Enkephalin

登录查看公司和协议定价
所有图片(2)

About This Item

经验公式（希尔记法）:
C28H37N5O7 · xC2H4O2 · yH2O
分子量:
555.62 (anhydrous free base basis)
MDL编号:
MFCD11045938
UNSPSC代码:
12352209
eCl@ss:
32160409
PubChem化学物质编号:
329817669
NACRES:
NA.32

质量水平

200

方案

≥95% (HPLC)

储存温度

−20°C

SMILES字符串

O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O

InChI

1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1

InChI key

QKDIOZBQOQJXFR-XQCXOTTHSA-N

基因信息

human ... OPRD1(4985) , OPRM1(4988)
mouse ... OPRD1(18386) , OPRM1(18390)
rat ... OPRD1(24613) , OPRM1(25601)

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu

一般描述

亮氨酸脑啡肽是一种五肽，是中央和周围组织的正常成分。亮氨酸脑啡肽的氨基酸序列为 Tyr-Gly-Gly-Phe-Leu，分布在包括人在内的多种动物的大脑中。它是一种内源性阿片类神经递质/神经调节剂，位于大脑中和δ受体类似的位置。

应用

亮氨酸脑啡肽乙酸盐盐水合物已用于单级 TOF 模式下 Q-Tof Micro 混合，三重四极杆正交飞行时间（TOF）质谱仪的校准。它也已用于进行质谱的校准。它也已被用于液相色谱-质谱（LCMS）/ MS 中进行系统校准和光谱的相对校正。

生化/生理作用

亮氨酸脑啡肽（LEU-ENK）在 μ-和 δ-阿片受体位点均起激动剂的作用。它也可能在吗啡敏感的突触中充当神经递质。亮氨酸脑啡肽还与疼痛调节有关。骆驼泪神经中表达的 LEU-ENK 调节泪液和蛋白质分泌。LEU-ENK 在代谢过程中会被多种酶降解，包括氨基肽酶 N（APN）、中性内肽酶（NEP）、二肽基肽酶 3（DPP3）、羧基肽酶 A6（CP​​A-6）和血管紧张素转换酶（ACE），有时也称为脑啡肽酶。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000388527
0000388529
0000329611
0000329608
0000369565

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application in farmers and consumers.
Thiphom S
Analytical Methods : Advancing Methods and Applications, 4(11), 3772-3778 (2012)
J Hughes et al.
Nature, 258(5536), 577-580 (1975-12-18)
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by
S R George et al.
The Journal of biological chemistry, 275(34), 26128-26135 (2000-06-08)
The existence of dimers and oligomers for many G protein-coupled receptors has been described by us and others. Since many G protein-coupled receptor subtypes are highly homologous to each other, we examined whether closely related receptors may interact with each
F Bolacchi et al.
Neurochemical research, 21(8), 875-884 (1996-08-01)
The hydrolysis of leucine enkephalin by the proteolytic enzymes present in human and rabbit plasma has been studied by kinetic and chromatographic techniques. Data obtained indicate the existence of noticeable intraspecific differences in the kinetics of leu-enkephalin degradation, and of
A P Sayani et al.
Journal of pharmaceutical sciences, 82(11), 1179-1185 (1993-11-01)
Leucine enkephalin (Tyr-Gly-Gly-Phe-Leu; Leu-Enk) is a naturally occurring peptide that has been shown to have pain modulating properties. To evaluate the feasibility of using various absorptive mucosae as a route of systemic delivery, the stability of Leu-Enk and the effect
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门