所有图片(2)
About This Item
经验公式（希尔记法）:
C28H37N5O7 · xC2H4O2 · yH2O
分子量:
555.62 (anhydrous free base basis)
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160409
PubChem化学物质编号:
NACRES:
NA.32
质量水平
检测方案
≥95% (HPLC)
储存温度
−20°C
SMILES字符串
O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
InChI
1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
InChI key
QKDIOZBQOQJXFR-XQCXOTTHSA-N
基因信息
human ... OPRD1(4985) , OPRM1(4988)
mouse ... OPRD1(18386) , OPRM1(18390)
rat ... OPRD1(24613) , OPRM1(25601)
Amino Acid Sequence
Tyr-Gly-Gly-Phe-Leu
一般描述
亮氨酸脑啡肽是一种五肽，是中央和周围组织的正常成分。亮氨酸脑啡肽的氨基酸序列为 Tyr-Gly-Gly-Phe-Leu，分布在包括人在内的多种动物的大脑中。它是一种内源性阿片类神经递质/神经调节剂，位于大脑中和δ受体类似的位置。
应用
亮氨酸脑啡肽乙酸盐盐水合物已用于单级 TOF 模式下 Q-Tof Micro 混合，三重四极杆正交飞行时间（TOF）质谱仪的校准。它也已用于进行质谱的校准。它也已被用于液相色谱-质谱（LCMS）/ MS 中进行系统校准和光谱的相对校正。
生化/生理作用
亮氨酸脑啡肽（LEU-ENK）在 μ-和 δ-阿片受体位点均起激动剂的作用。它也可能在吗啡敏感的突触中充当神经递质。亮氨酸脑啡肽还与疼痛调节有关。骆驼泪神经中表达的 LEU-ENK 调节泪液和蛋白质分泌。LEU-ENK 在代谢过程中会被多种酶降解，包括氨基肽酶 N（APN）、中性内肽酶（NEP）、二肽基肽酶 3（DPP3）、羧基肽酶 A6（CPA-6）和血管紧张素转换酶（ACE），有时也称为脑啡肽酶。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Zhuo Cheng et al.
Frontiers in plant science, 11, 965-965 (2020-07-17)
Plants in Acorus have been used as herbal medicine by various linguistic groups for thousands of years. Arguments of taxonomy of Acorus among scientists resulted in confusions and misuses of Acorus plants. The present study used different methods to investigate
Biological effects of Trichoderma harzianum peptaibols on mammalian cells
Peltola J, et al.
Applied and Environmental Microbiology, 70(8), 4996-5004 (2004)
F Bolacchi et al.
Neurochemical research, 21(8), 875-884 (1996-08-01)
The hydrolysis of leucine enkephalin by the proteolytic enzymes present in human and rabbit plasma has been studied by kinetic and chromatographic techniques. Data obtained indicate the existence of noticeable intraspecific differences in the kinetics of leu-enkephalin degradation, and of
S R George et al.
The Journal of biological chemistry, 275(34), 26128-26135 (2000-06-08)
The existence of dimers and oligomers for many G protein-coupled receptors has been described by us and others. Since many G protein-coupled receptor subtypes are highly homologous to each other, we examined whether closely related receptors may interact with each
J Hughes et al.
Nature, 258(5536), 577-580 (1975-12-18)
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by
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