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Merck
CN

L8643

Sigma-Aldrich

脂多糖 来源于绿脓假单胞菌 10

purified by gel-filtration chromatography

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别名:
LPS
MDL编号:
UNSPSC代码:
12352201
NACRES:
NA.25

生物来源

Pseudomonas aeruginosa (10)

质量水平

形式

lyophilized powder

纯化方式

gel-filtration chromatography

杂质

<3% Protein (Lowry)

颜色

white to faint yellow

溶解性

water: 4.90-5.10 mg/mL, cloudy to hazy, colorless to faintly yellow

储存温度

2-8°C

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应用

来自 绿脓杆菌 10 的脂多糖已被用作细胞中的炎症介质。
脂多糖 (LPS) 是革兰氏阴性菌细胞壁的特征性成分。LPS 及其脂质 A 部分通过 Toll 样受体 4 (TLR4) 刺激先天免疫系统的细胞,TLR4 是 Toll 样受体蛋白家族的成员之一,可识别常见的病原体相关分子模式 (PAMP)。

其他说明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice.
Bruscia EM
American Journal of Respiratory Cell and Molecular Biology, 40, 295-295 (2009)
Austin Boucher et al.
Journal of immunology (Baltimore, Md. : 1950), 206(3), 540-553 (2020-12-18)
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for miRs-23a, -27a, and -24-2, regulates mouse macrophage polarization.
Sandra Chang et al.
PloS one, 10(7), e0131810-e0131810 (2015-07-07)
Oxidant production from DUOX1 has been proposed to lead to neutrophil recruitment into the airways when lung homeostasis is compromised. The objective of this study was to determine whether DUOX-derived hydrogen peroxide is required for LPS-induced neutrophil recruitment, using a
Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha.
Russell JP
Infection and Immunity, 64, 1565-1565 (1996)
Clara cells attenuate the inflammatory response through regulation of macrophage behavior.
Snyder JC
American Journal of Respiratory Cell and Molecular Biology, 42, 161-171 (2010)

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