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Merck
CN

L7016

Sigma-Aldrich

单克隆抗 LDH(H 亚单位) 小鼠抗

clone HH-17, ascites fluid

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别名:
Anti-Lactic Dehydrogenase (H-Subunit)
MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.46

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

HH-17, monoclonal

包含

15 mM sodium azide

种属反应性

human

技术

indirect ELISA: 1:5,000

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... LDHB(3945)

相关类别

一般描述

Lactate dehydrogenase (LDH) is an NADH-dependent enzyme that catalyzes the reversible conversion of pyruvate to lactate. Human LDH has two known isoforms, the H isoform which is primarily found in heart tissues and the M isoform that occurs mostly in muscle tissues.
Monoclonal Anti-LDH (H-Subunit) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

免疫原

Human LDH-H4 isoenzyme

应用

Monoclonal Anti-LDH (H-Subunit) antibody produced in mouse has been used in:
  • immunoblotting†
  • immunohistochemistry
  • microscopy

生化/生理作用

Lactate dehydrogenase (LDH) is an NADH-dependent enzyme that catalyzes the reversible conversion of pyruvate to lactate.
Lactate dehydrogenase (LDH) is an NADH-dependent enzyme that catalyzes the reversible conversion of pyruvate to lactate. Human LDH has two known isoforms, the H isoform which is primarily found in heart tissues and the M isoform that occurs mostly in muscle tissues . Ratio of LDH isozymes H4 and H3M can be used as diagnostic and prognostic markers of myocardial infarction . Monoclonal Anti-Human Lactate Dehydrogenase is specific for human LDH isozymes containing the H-subunit. The antibody does not cross-react with the M4 isozyme.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity
Dyer PDR, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 220, 316-328 (2015)
Lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer
Leiblich A, et al.
Oncogene, 25(20), 2953-2953 (2006)
N R Acharya et al.
Advances in myocardiology, 2, 407-414 (1980-01-01)
The isozyme profile of lactic dehydrogenase (LDH) is being studied in this laboratory, mainly for the diagnosis in the suspected cases of myocardial infarction (MI). The isozymes are separated by polyacrylamide gel electrophoresis and the quantitative assay of the isoenzymes
NAD-dependent lactate dehydrogenase catalyses the first step in respiratory utilization of lactate by Lactococcus lactis
Zhao R, et al.
FEBS Open Bio, 3, 379-386 (2013)
Andrei Seluanov et al.
DNA repair, 6(12), 1740-1748 (2007-08-10)
Aging is associated with accumulation of genomic rearrangements consistent with aberrant repair of DNA breaks. We have shown previously that DNA repair by non-homologous end joining (NHEJ) becomes less efficient and more error-prone in senescent cells. Here, we show that

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