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Merck
CN

L4762

洛哌丁胺 盐酸盐

98-102% (USP), powder, Ca2+ channel blocker

别名:

4-（ p -氯苯基）-4-羟基- N,N -二甲基-α,α-二苯基-1-哌啶丁酰胺 盐酸盐

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关于此项目

经验公式（希尔记法）:
C29H33ClN2O2 · HCl
化学文摘社编号:
34552-83-5
分子量:
513.50
NACRES:
NA.77
PubChem Substance ID:
24278042
UNSPSC Code:
12352200
EC Number:
252-082-4
MDL number:
MFCD00058581

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产品名称

洛哌丁胺 盐酸盐,

InChI key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

InChI

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

SMILES string

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

originator

Johnson & Johnson

Quality Level

200

Gene Information

human ... OPRM1(4988)

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相关类别

Application

盐酸洛哌丁胺 (HCl) 已用于炎性疼痛实验和评估蛋白质的功能性。54

Biochem/physiol Actions

盐酸洛哌丁胺 (HCl) 是一种非选择性 Ca 2 + 通道阻滞剂。在纳摩尔浓度下，与 μ-阿片受体。盐酸洛哌丁胺不能通过血脑屏障。

Features and Benefits

该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

Preparation Note

微溶于水和稀酸，易溶于甲醇和氯仿，可溶于95%乙醇。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000406508
0000406508
0000340740
0000312729
0000340740

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J Church et al.
Molecular pharmacology, 45(4), 747-757 (1994-04-01)
The effects of the antidiarrheal agent loperamide on high-voltage-activated (HVA) calcium channel activity and excitatory amino acid-evoked responses in two preparations of cultured hippocampal pyramidal neurons were examined. In rat hippocampal neurons loaded with the calcium-sensitive dye fura-2, rises in
Olivia Benguettat et al.
PLoS pathogens, 14(9), e1007279-e1007279 (2018-09-05)
The digestive tract is the first organ affected by the ingestion of foodborne bacteria. While commensal bacteria become resident, opportunistic or virulent bacteria are eliminated from the gut by the local innate immune system. Here we characterize a new mechanism
Raphaël Weibel et al.
PloS one, 8(9), e74706-e74706 (2013-09-27)
Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to
Halil Kacmaz et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 33(2), e13994-e13994 (2020-10-02)
Gastrointestinal (GI) motility is a complex physiological process that is critical for normal GI function. Disruption of GI motility frequently occurs in GI diseases or as side effects of therapeutics. Whole gut transit measurements, like carmine red leading-edge transit, in
Min Guk Kim et al.
Journal of personalized medicine, 10(4) (2020-10-15)
Unbalanced dietary habits and the consumption of high protein and instant foods cause an increase in constipation. Here, we evaluated the effects of galacto-oligosaccharide (GOS) on a rat model of loperamide-induced constipation by measuring various biological markers and cecal microbiota.
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