L4021
催乳素 人
recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)
别名:
hPRL, LTH, PRL, 促黄体激素, 催乳激素
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关于此项目
Biological source:
Escherichia coli
Form:
lyophilized powder
Assay:
>97% (SDS-PAGE)
biological source
Escherichia coli
recombinant
expressed in E. coli
description
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
product line
BioReagent
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.030-0.300 ng/mL EC50
mol wt
predicted mol wt ~24 kDa
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
solubility
water: 0.5000 mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... PRL(5617)
Application
可用在细胞培养应用中研究催乳素对细胞信号传导和基因表达的调节。
Biochem/physiol Actions
催乳素是一种神经内分泌激素。催乳激素受体是一种跨膜糖蛋白，属于细胞因子造血受体家族。大量细胞和器官表达该受体，包括 B 细胞、T 细胞、巨噬细胞、单核细胞和嗜中性粒细胞。催乳素信号转导涉及 JAK/STAT 家族和 src 激酶家族。引起泌乳；抑制促性腺激素的分泌；释放受多巴胺抑制。
神经内分泌激素；属于细胞因子造血受体家族；诱导泌乳；抑制促性腺激素的分泌；释放受多巴胺抑制。
Physical form
从 10mM 磷酸盐和 50mM 氯化钠溶液（pH 8.0）中冻干。
Preparation Note
建议将无菌 4 mM HCl（含 1 mg/mL 牛血清白蛋白）添加到小瓶中，以制备不低于 100 μg/mL 的储液。
Analysis Note
生物学活性是通过大鼠淋巴瘤细胞系 Nb2-11 的增殖实验测定的。
Other Notes
包含天然产物中不存在的 N 末端甲硫氨酸。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells.
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Bibiana Moreno-Carranza et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R720-R726 (2013-08-21)
Prolactin (PRL) is a potent liver mitogen and proangiogenic hormone. Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH). Liver-to-body weight ratio
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
Gerda de Kuijper et al.
Research in developmental disabilities, 34(9), 2799-2809 (2013-06-25)
Individuals with intellectual disability frequently use antipsychotics for many years. This may have detrimental health effects, including neurological symptoms and metabolic and hormonal dysregulation, the latter possibly affecting bone metabolism. There is large variability in the degree in which antipsychotic
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