L4021
催乳素 人
recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)
别名:
hPRL, LTH, PRL, 促黄体激素, 催乳激素
登录 查看组织和合同定价。
选择尺寸
关于此项目
Biological source:
Escherichia coli
Form:
lyophilized powder
Assay:
>97% (SDS-PAGE)
产品名称
催乳素 人, recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)
biological source
Escherichia coli
recombinant
expressed in E. coli
description
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
product line
BioReagent
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.030-0.300 ng/mL EC50
mol wt
predicted mol wt ~24 kDa
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
solubility
water: 0.5000 mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... PRL(5617)
Biochem/physiol Actions
催乳素是一种神经内分泌激素。催乳激素受体是一种跨膜糖蛋白，属于细胞因子造血受体家族。大量细胞和器官表达该受体，包括 B 细胞、T 细胞、巨噬细胞、单核细胞和嗜中性粒细胞。催乳素信号转导涉及 JAK/STAT 家族和 src 激酶家族。引起泌乳；抑制促性腺激素的分泌；释放受多巴胺抑制。
神经内分泌激素；属于细胞因子造血受体家族；诱导泌乳；抑制促性腺激素的分泌；释放受多巴胺抑制。
Other Notes
包含天然产物中不存在的 N 末端甲硫氨酸。
Physical form
从 10mM 磷酸盐和 50mM 氯化钠溶液（pH 8.0）中冻干。
Preparation Note
建议将无菌 4 mM HCl（含 1 mg/mL 牛血清白蛋白）添加到小瓶中，以制备不低于 100 μg/mL 的储液。
Analysis Note
生物学活性是通过大鼠淋巴瘤细胞系 Nb2-11 的增殖实验测定的。
Application
可用在细胞培养应用中研究催乳素对细胞信号传导和基因表达的调节。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells.
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Massimo Costanza et al.
Journal of immunology (Baltimore, Md. : 1950), 191(5), 2082-2088 (2013-07-26)
Predominance of multiple sclerosis (MS) in women, reductions of disease flares during pregnancy, and their increase in the postpartum period have suggested a hormonal influence on MS activity. The hormone prolactin (PRL) has long been debated as a potential immune-stimulating
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持