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COO原产地证书/COA分析证书

L3024

脂多糖来源于大肠杆菌 0111:B4

Name: 脂多糖 来源于<I>大肠杆菌 </I> 0111:B4
Brand: SIGMA

purified by ion-exchange chromatography, TLR ligand tested

别名:

LPS

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About This Item

EC 号:

297-473-0

MDL编号:

MFCD00164401

UNSPSC代码:

12352201

NACRES:

NA.25

生物来源

Escherichia coli (O111:B4)

质量水平

200

形式

lyophilized powder

纯化方式

ion-exchange chromatography

杂质

<1% Protein
<1% RNA

颜色

white to yellow cast

溶解性

water: soluble

运输

ambient

储存温度

2-8°C

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一般描述

该产品是从大肠杆菌血清型O111：B4中提取的，并已通过离子交换进行纯化。来源菌株来自私人保藏。该LPS血清型已用于刺激B细胞并诱导人肝细胞中的NOS。

应用

脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。

生化/生理作用

脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。

制备说明

该产品可溶于水（5mg/mL）或细胞培养基（1mg/mL），并产生浑浊的淡黄色溶液。在涡旋震荡并升温至70-80℃后，可在盐水溶液中获得更加浓缩但仍然浑浊的溶液（20mg/mL）。脂多糖可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。通过有机溶剂无法获得更澄清的溶液。在甲醇会产生含有漂浮物的混浊悬浮液，而在水中则产生均匀的浑浊溶液。

其他说明

为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。

警示用语：

Danger

危险声明

H300

预防措施声明

P264 - P270 - P301 + P310 - P405 - P501

危险分类

Acute Tox. 2 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.

Yoshitomo Hayama et al.

Journal of immunology (Baltimore, Md. : 1950), 200(11), 3790-3800 (2018-04-25)

Amino acid metabolism plays important roles in innate immune cells, including macrophages. Recently, we reported that a lysosomal adaptor protein, Lamtor1, which serves as the scaffold for amino acid-activated mechanistic target of rapamycin complex 1 (mTORC1), is critical for the

The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach.

Carl-Fredrik Johnzon et al.

Frontiers in immunology, 9, 1487-1487 (2018-07-11)

Mastitis is an inflammatory condition of the mammary tissue and represents a major problem for the dairy industry worldwide. The present study was undertaken to study how experimentally induced acute bovine mastitis affects inflammatory parameters and changes in the metabolome.

Effects of differential supplementation of fatty acids during the peripartum and breeding periods of Holstein cows: II. Neutrophil fatty acids and function, and acute phase proteins.

F T Silvestre et al.

Journal of dairy science, 94(5), 2285-2301 (2011-04-29)

The objectives were to evaluate the effects of differential supplementation of Ca salts (CS) of fatty acids (FA) on plasma acute phase proteins and both FA composition and function (i.e., activity and cytokine production) of neutrophils, during the peripartum and

Neutrophil recruitment in endotoxin-induced murine mastitis is strictly dependent on mammary alveolar macrophages.

Sharon Elazar et al.

Veterinary research, 41(1), 10-10 (2009-10-16)

Mastitis, inflammation of the mammary tissue, is a common disease in dairy animals and mammary pathogenic Escherichia coli (MPEC) is a leading cause of the disease. Lipopolysaccharide (LPS) is an important virulence factor of MPEC and inoculation of the mammary

Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer.

Jessica E S Shay et al.

Carcinogenesis, 35(5), 1067-1077 (2014-01-11)

Hypoxia-inducible factors (HIFs) accumulate in both neoplastic and inflammatory cells within the tumor microenvironment and impact the progression of a variety of diseases, including colorectal cancer. Pharmacological HIF inhibition represents a novel therapeutic strategy for cancer treatment. We show here

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脂多糖 来源于大肠杆菌 0111:B4