L2898
溶葡球菌酶 来源于溶葡萄球菌
aseptically filled
别名:
甘氨酰-甘氨酸内肽酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
>500 units/mg protein
General description
化学结构：肽
溶葡萄球菌酶主要以酶原的形式释放出来。在 pH 4 和温度 5℃ 时高度稳定。
Biochem/physiol Actions
溶葡萄球菌素是一种分子量约为25 kDa的锌内肽酶。 由于溶葡萄球菌酶能裂解 葡萄球菌 类细胞壁肽聚糖层中的聚甘氨酸交联键，它已被发现可用于细胞裂解，并具有潜在的抗菌治疗作用。
活性最佳pH：约 7.5
活性最佳pH：约 7.5
溶葡萄球菌酶表现出对 金黄色葡萄球菌的溶解作用 。它拥有三种主要酶甘氨酸内肽酶（溶葡萄球菌酶、内切β- N -乙酰基葡萄糖苷酶和 N -乙酸乙酯基- L -丙氨酸酰胺酶）的数种功能。溶葡萄球菌酶可用于治疗耐抗生素的葡萄球菌感染。溶葡萄球菌酶是一种抗葡萄球菌剂，可用作食品工业和临床实验室的防腐剂，用于快速筛查。
Preparation Note
从L 7386制备
Other Notes
在 pH 7.5、37℃、6.0 mL 反应混合液中，1 个单位可在 10 min 内将 金黄色葡萄球菌 细胞混悬液的浊度 (A 620 ) 从 0.250 降至 0.125。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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A P Desbois et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 30(8), 1015-1021 (2011-02-12)
Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents. There has been a resurgence in interest in using lysostaphin (a specific anti-staphylococcal enzyme) as a treatment for infections caused by these important pathogens. However
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