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L2407

Luzindole

Name: Luzindole
Brand: SIGMA

≥90%, melatonin receptor antagonist

别名:

N-[2-[2-(苯基甲基)-1H-吲哚-3-基]乙基]乙酰胺, N-乙酰基-2-苄基色胺

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₀N₂O

化学文摘社编号:

117946-91-5

分子量:

292.37

UNSPSC Code:

12352200

PubChem Substance ID:

24896315

NACRES:

NA.77

MDL number:

MFCD00672498

Assay:

≥90%

Quality level:

200

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属性

产品名称

Luzindole, ≥90%

Quality Level

200

assay

≥90%

solubility

DMSO: 5 mg/mL

storage temp.

−20°C

SMILES string

CC(=O)NCCc1c(Cc2ccccc2)[nH]c3ccccc13

InChI

1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)

InChI key

WVVXBPKOIZGVNS-UHFFFAOYSA-N

Gene Information

human ... MTNR1A(4543), MTNR1B(4544)

说明

Application

Luzindole已被用作MT1/MT2受体拮抗剂，用于检测褪黑激素受体在嗜中性粒细胞迁移中的作用

Biochem/physiol Actions

Luzindole是一种褪黑激素（mel）受体拮抗剂。它对Mel 1b受体的亲和力高于Mel 1a受体亚型。

Features and Benefits

该化合物在受体分类和信号转导手册的褪黑素受体页面上有详细描述。如需浏览其他手册页面，请点击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000542478

0000316322

SLCR3744

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Physiological crosstalk between melatonin and glucocorticoid receptor modulates T-cell mediated immune responses in a wild tropical rodent, Funambulus pennanti.

Sameer Gupta et al.

The Journal of steroid biochemistry and molecular biology, 134, 23-36 (2012-10-13)

Immunoenhancing attributes of melatonin (Mel) on the immunocompromised state induced by glucocorticoid is well known, but the involvement of their receptors in the modulation of immunity has never been studied in any rodent. The present study explores the role of

Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist

Drazen DL, et al.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 280(5), R1476-R1482 (2001)

Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction.

Naree Song et al.

Journal of pineal research, 53(4), 335-343 (2012-04-28)

Melatonin is an indolamine that is synthesized in the pineal gland and shows a wide range of physiological functions. Although the anti-aging properties of melatonin have been reported in a senescence-accelerated mouse model, whether melatonin modulates cellular senescence has not

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全球贸易项目编号

货号	GTIN
L2407-5MG	04061833950050