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Merck
CN

L2407

Sigma-Aldrich

Luzindole

≥90%

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别名:
N-[2-[2-(苯基甲基)-1H-吲哚-3-基]乙基]乙酰胺, N-乙酰基-2-苄基色胺
经验公式(希尔记法):
C19H20N2O
分子量:
292.37
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥90%

溶解性

DMSO: 5 mg/mL

储存温度

−20°C

SMILES字符串

CC(=O)NCCc1c(Cc2ccccc2)[nH]c3ccccc13

InChI

1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)

InChI key

WVVXBPKOIZGVNS-UHFFFAOYSA-N

基因信息

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应用

Luzindole已被用作MT1/MT2受体拮抗剂,用于检测褪黑激素受体在嗜中性粒细胞迁移中的作用

生化/生理作用

Luzindole是一种褪黑激素(mel)受体拮抗剂。它对Mel 1b受体的亲和力高于Mel 1a受体亚型。

特点和优势

该化合物在受体分类和信号转导手册的 褪黑素受体 页面上有详细描述。如需浏览其他手册页面,请点击此处

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Sameer Gupta et al.
The Journal of steroid biochemistry and molecular biology, 134, 23-36 (2012-10-13)
Immunoenhancing attributes of melatonin (Mel) on the immunocompromised state induced by glucocorticoid is well known, but the involvement of their receptors in the modulation of immunity has never been studied in any rodent. The present study explores the role of
Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist
Drazen DL, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 280(5), R1476-R1482 (2001)
Naree Song et al.
Journal of pineal research, 53(4), 335-343 (2012-04-28)
Melatonin is an indolamine that is synthesized in the pineal gland and shows a wide range of physiological functions. Although the anti-aging properties of melatonin have been reported in a senescence-accelerated mouse model, whether melatonin modulates cellular senescence has not
Richard B Rosen et al.
Molecular vision, 18, 1640-1648 (2012-07-10)
Recently, we reported finding that circulating melatonin levels in age-related macular degeneration patients were significantly lower than those in age-matched controls. The purpose of this study was to investigate the hypothesis that melatonin deficiency may play a role in the
Rafael Ochoa-Sanchez et al.
Progress in neuro-psychopharmacology & biological psychiatry, 39(2), 318-325 (2012-07-14)
Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein-coupled receptors, denoted MT(1) and MT(2). However, the particular role of

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