L135
L-741,626
≥98% (HPLC)
别名:
(±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole
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关于此项目
经验公式（希尔记法）:
C20H21ClN2O
化学文摘社编号:
分子量:
340.85
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
L-741,626, ≥98% (HPLC)
InChI
1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
SMILES string
OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4
InChI key
LLBLNMUONVVVPG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥20 mg/mL
ethanol: 24 mg/mL
H2O: insoluble
storage temp.
room temp
Quality Level
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815)
Application
L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.
Biochem/physiol Actions
L-741,626 is a selective dopamine (D2) receptor antagonist.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
F Chaperon et al.
Neuropharmacology, 44(8), 1047-1053 (2003-05-24)
The dopamine D(3) receptor agonist PD 128907 decreased body temperature in the rat. The selective dopamine D(3) and D(4) receptor antagonists, A-437203 and L-745,870, respectively, did not prevent this effect. In contrast, PD 128907-induced hypothermia was antagonized by SCH 23390
Diego Luis-Ravelo et al.
Pharmacological research, 165, 105434-105434 (2021-01-24)
The dopamine transporter (DAT) is a membrane glycoprotein in dopaminergic neurons, which modulates extracellular and intracellular dopamine levels. DAT is regulated by different presynaptic proteins, including dopamine D2 (D2R) and D3 (D3R) receptors. While D2R signalling enhances DAT activity, some
Naomi P Visanji et al.
Experimental neurology, 202(1), 85-92 (2006-07-04)
The role of D(3) receptors in the antiparkinsonian actions of l-DOPA and l-DOPA-induced dyskinesia (LID) remains unclear. The D(3) receptor partial agonist BP897 attenuates LID in primates without affecting the antiparkinsonian actions of l-DOPA, suggesting that "normalization" of D(3) activity
Ferran Jardí et al.
Scientific reports, 8(1), 957-957 (2018-01-19)
Low testosterone (T) in men, especially its free fraction, has been associated with loss of energy. In accordance, orchidectomy (ORX) in rodents results in decreased physical activity. Still, the mechanisms through which T stimulates activity remain mostly obscure. Here, we
David J G Watson et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(3), 770-786 (2011-10-28)
Dopamine D(3) receptor antagonists exert pro-cognitive effects in both rodents and primates. Accordingly, this study compared the roles of dopamine D(3) vs D(2) receptors in social novelty discrimination (SND), which relies on olfactory cues, and novel object recognition (NOR), a
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