L131
L-745,870 hydrochloride
别名:
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine hydrochloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H19ClN4 · HCl
化学文摘社编号:
分子量:
363.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H
SMILES string
Cl.Clc1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34
InChI key
GFFJYISJZJIKAF-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: 0.2 mg/mL
ethanol: 1.4 mg/mL
0.1 M HCl: 5.5 mg/mL
Quality Level
Gene Information
human ... DRD4(1815)
Biochem/physiol Actions
Selective D4 dopamine receptor antagonist.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S. for use solely for preclinical researchy purposes (i.e., not for the administration to or other use in humans).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
S Patel et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 636-647 (1997-11-14)
L-745,870,(3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H- pyrollo[2,3-b] pyridine, was identified as a selective dopamine D4 receptor antagonist with excellent oral bioavailability and brain penetration. L-745,870 displaced specific binding of 0.2 nM [3H] spiperone to cloned human dopamine D4 receptors with a binding affinity (Ki) of
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