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表单
solid
质量水平
颜色
white
溶解性
H2O: 0.2 mg/mL
ethanol: 1.4 mg/mL
0.1 M HCl: 5.5 mg/mL
SMILES字符串
Cl.Clc1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34
InChI
1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H
InChI key
GFFJYISJZJIKAF-UHFFFAOYSA-N
基因信息
human ... DRD4(1815)
生化/生理作用
Selective D4 dopamine receptor antagonist.
特点和优势
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
法律信息
Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S. for use solely for preclinical researchy purposes (i.e., not for the administration to or other use in humans).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Patel et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 636-647 (1997-11-14)
L-745,870,(3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H- pyrollo[2,3-b] pyridine, was identified as a selective dopamine D4 receptor antagonist with excellent oral bioavailability and brain penetration. L-745,870 displaced specific binding of 0.2 nM [3H] spiperone to cloned human dopamine D4 receptors with a binding affinity (Ki) of
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