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Merck
CN

L119

Sigma-Aldrich

L-703,606 草酸盐 水合物

solid

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别名:
顺式-2-(二苯基甲基)-N-[(2-碘苯基)甲基]-1-氮杂双环[2.2.2]辛-3-胺 草酸盐
经验公式(希尔记法):
C27H29IN2 · C2H2O4 · xH2O
分子量:
598.47 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

形式

solid

质量水平

储存条件

desiccated

颜色

white

溶解性

DMSO: >10 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 11 mg/mL
H2O: slightly soluble <2 mg/mL

SMILES字符串

O.OC(=O)C(O)=O.Ic1ccccc1CN[C@@H]2C3CCN(CC3)[C@@H]2C(c4ccccc4)c5ccccc5

InChI

1S/C27H29IN2.C2H2O4.H2O/c28-24-14-8-7-13-23(24)19-29-26-22-15-17-30(18-16-22)27(26)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21;3-1(4)2(5)6;/h1-14,22,25-27,29H,15-19H2;(H,3,4)(H,5,6);1H2/t26-,27-;;/m1../s1

InChI key

NJAUFRHNYIJKDW-AJUXDCMMSA-N

基因信息

human ... TACR1(6869)

相关类别

生化/生理作用

强效选择性非肽NK-1速激肽受体拮抗剂。

注意

吸湿

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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M A Cascieri et al.
Molecular pharmacology, 42(3), 458-463 (1992-09-01)
We have synthesized a potent, selective, radioiodinated antagonist of the human neurokinin-1 (NK1) receptor and have characterized its binding to the cloned receptor expressed in Chinese hamster ovary cells. (cis)-2-(Diphenylmethyl)-N-[(2-iodophenyl)-methyl]-1- azabicyclo[2.2.2]octan-3-amine (L-703606) inhibits binding of 125I-Tyr8-substance P to the human
T M Fong et al.
The Journal of biological chemistry, 267(36), 25664-25667 (1992-12-25)
To identify the molecular determinants of ligand-receptor interactions, the extracellular domain of the human neurokinin-1 receptor was systematically substituted with the corresponding sequences from the other two neurokinin receptor subtypes. Three residues within the first extracellular segment and 2 residues
Ki Bum Um et al.
eLife, 10 (2021-08-20)
Midbrain dopamine (DA) neurons are slow pacemakers that maintain extracellular DA levels. During the interspike intervals, subthreshold slow depolarization underlies autonomous pacemaking and determines its rate. However, the ion channels that determine slow depolarization are unknown. Here we show that

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