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Merck
CN

L1026

利多卡因

Na+ channel blocker, solid

别名:

2-二乙氨基-N-（2,6-二甲苯基）乙酰胺, 利多卡因, 赛洛卡因

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关于此项目

经验公式（希尔记法）:
C14H22N2O
化学文摘社编号:
137-58-6
分子量:
234.34
NACRES:
NA.77
PubChem Substance ID:
24896272
UNSPSC Code:
12352200
EC Number:
205-302-8
MDL number:
MFCD00026733

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产品名称

利多卡因, analytical standard

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

grade

analytical standard

form

solid

packaging

vial of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% Total Organic Impurities (Lidocaine related compound H ≤0.10%


2,6-Dimethylaniline ≤0.01%


Any unspecified impurity ≤0.10%


Total impurities ≤0.5%)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

Quality Level

200

Gene Information

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

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相关类别

Application

Lidocaine has been used to examine its effects in inhibiting lymph flow and protection against envenomation. It has also been used to assess its efficacy as an anti-tussive agent.

General description

Lidocaine is an amide anesthetic, which is used to treat ventricular arrhythmias. It lowers cardiac automaticity and myocardial conduction. Lidocaine inhibits the generation and conduction of nerve impulses. It has an anticonvulsant effect.

Packaging

Supplied in amber screw-cap vials

Biochem/physiol Actions

Na+通道阻滞剂；IB类抗心律失常药。
Na+通道阻滞剂；在肠胃外给药后可迅速被吸收的IB类抗心律失常药。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000490804
0000490804
SLCF7788
SLBV4350
SLBJ7206V

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Seizures in Critical Care: A Guide to Diagnosis and Therapeutics (2008)
Pharmacological approaches that slow lymphatic flow as a snakebite first aid
van Helden DF, et al.
PLoS Neglected Tropical Diseases, 8(2), e2722-e2722 (2014)
Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs
Venkatasamy R, et al.
Journal of Pharmacological and Toxicological Methods, 61(2), 157-162 (2010)
Key Issues in Plastic and Cosmetic Surgery (1999)
Anesthesiology Keywords Review (2008)
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