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安全信息

L0520

Sigma-Aldrich

乳铁蛋白 来源于人奶

≥85% (SDS-PAGE), lyophilized powder

别名:

Growth-inhibiting protein 12, Lactotransferrin, Talalactoferrin

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About This Item

CAS号:
936541-36-5
MDL编号:
MFCD00164307
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

human milk

质量水平

200

检测方案

≥85% (SDS-PAGE)

形式

lyophilized powder

分子量

82.4 kDa

组成

Protein, ≥90% biuret

技术

microbiological culture: suitable

溶解性

phosphate buffer: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 °C)

UniProt登记号

P02788

储存温度

2-8°C

InChI

1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1

InChI key

QCBUWCQOKPLTDZ-PKRULZLPSA-N

基因信息

human ... LTF(4057)

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应用

乳铁蛋白用于在铁限制培养基中生长变形链球菌。 它用于测试乳铁蛋白是否在体外阻止上皮细胞粘附。

生化/生理作用

乳铁蛋白是一种铁结合蛋白。在结构上与血浆铁转运蛋白转铁蛋白相似；但是乳铁蛋白对铁的亲和力要高得多（250 倍）。在初乳中含量非常丰富，少量也可见于泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中。由粘膜上皮和中性粒细胞组成，在炎症刺激下由这些细胞释放。细菌的生长被其隔离铁的能力所抑制，也通过其 N 端与脂多糖结合使细菌细胞壁通透性增加。乳铁蛋白可以通过与病毒包膜蛋白紧密结合来抑制病毒感染。它通过阻断结合域阻止了细胞与病毒的融合。乳铁蛋白似乎部分通过刺激中性粒细胞激活剂白细胞介素-8 的释放来激活宿主防御系统。还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。

质量

包含铁，有关批次特异性信息，请参见检验报告。

制备说明

色谱纯化产品。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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