L0517
白三烯B4
≥97%, c-Fos stimulator, liquid
别名:
[5S，12R]-二羟基-[6Z，8E，10E，14Z]-二十碳四烯酸
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关于此项目
经验公式（希尔记法）:
C20H32O4
化学文摘社编号:
分子量:
336.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-578-6
MDL number:
产品名称
白三烯B4, ≥97%
InChI key
VNYSSYRCGWBHLG-AMOLWHMGSA-N
InChI
1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
SMILES string
CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
assay
≥97%
form
liquid
Quality Level
Gene Information
human ... LTB4R(1241)
rat ... Ltb4r(59264)
shipped in
dry ice
storage temp.
−20°C
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相关类别
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
57.2 °F - closed cup
flash_point_c
14.0 °C - closed cup
法规信息
危险化学品
此项目有
L Iversen et al.
The Journal of investigative dermatology, 100(3), 293-298 (1993-03-01)
In the present study, keratinocytes were coincubated with human neutrophils to determine whether or not an increase in leukotriene B4 formation can occur. Human keratinocytes used were cultured in serum-free, low-calcium medium, whereas neutrophils were purified from heparinized venous blood.
H E Claesson et al.
International journal of immunopharmacology, 14(3), 441-449 (1992-04-01)
Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to
Preeti Subramanian et al.
Investigative ophthalmology & visual science, 57(11), 4581-4588 (2016-09-17)
5-Lipoxygenase (5-LOX) oxygenates arachidonic acid to form 5-hydroperoxyeicosatetraenoic acid, which is further converted into biologically detrimental leukotrienes, such as leukotriene B4 (LTB4). The RPE and retina express the PNPLA2 gene for pigment epithelium-derived factor receptor (PEDF-R), a lipase involved in
Lloyd Tanner et al.
Journal of innate immunity, 12(3), 203-225 (2019-09-19)
Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide.
Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis.
Jesper Z Haeggström
The Journal of biological chemistry, 279(49), 50639-50642 (2004-09-02)
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Discover Bioactive Small Molecules for Lipid Signaling Research
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