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质量水平
检测方案
≥98% (HPLC)
形式
powder
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
off-white
溶解性
DMSO: >20 mg/mL (with heating)
储存温度
−20°C
SMILES字符串
CCCn1c(C)c(C(=O)c2cccc3ccccc23)c4ccccc14
InChI
1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3
InChI key
LJSBBBWQTLXQEN-UHFFFAOYSA-N
基因信息
human ... CNR2(1269)
rat ... Cnr1(25248)
应用
JWH-015 has been used to study its effect on tumor-evoked pain behavior. It has also been used to study its protective effects on rat brain mitochondria upon paraquat exposure.
生化/生理作用
JWH-015 is a selective CB2 cannabinoid receptor agonist. JWH-015 is structurally classified as naphthoylindoles.
特点和优势
This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Joseph E Henriquez et al.
Toxicology and applied pharmacology, 369, 82-89 (2019-02-27)
Plasmacytoid dendritic cells (pDC) compose 0.2-0.5% of circulating leukocytes but play a significant role in mounting host immune responses. Elevated and chronic activation of pDC are implicated in autoimmune disease like systemic lupus erythematosus and rheumatoid arthritis. Δ9-tetrahydrocannabinol (THC) is
Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-D-Aspartic Acid
XiaoPing G, et al.
Journal of Cell Science, jcs-100925 (2012)
Cui'e Lu et al.
Cellular and molecular neurobiology, 37(1), 101-109 (2016-03-05)
The objective of this study was to explore the potential role of G-protein-coupled receptor kinase 2 (GRK2) in the progression of cannabinoid 2 receptor (CB2) agonist-induced analgesic effects of bone cancer pain. Female Sprague-Dawley rats, weighing 160-180 g, were utilized to
Lirit N Franks et al.
Toxicology and applied pharmacology, 353, 31-42 (2018-06-16)
Selective estrogen receptor modulators (SERMs) target estrogen receptors (ERs) to treat breast cancer and osteoporosis. Several SERMs exhibit anti-cancer activity not related to ERs. To discover novel anti-cancer drugs acting via ER-independent mechanisms, derivatives of the SERM tamoxifen, known as
G Griffin et al.
European journal of pharmacology, 339(1), 53-61 (1998-02-05)
We have investigated whether there are cannabinoid CB2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the mouse vas deferens or guinea-pig myenteric plexus-longitudinal muscle preparation. Our results showed that mouse vas deferens and guinea-pig whole gut
商品
A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.
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