I7908
IL-2 human
≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture
别名:
IL-2, T细胞生长因子, 白细胞介素-2
产品名称
白细胞介素-2 人, recombinant, expressed in Pichia pastoris, suitable for cell culture
biological source
human
recombinant
expressed in Pichia pastoris
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
mol wt
predicted mol wt ~15 kDa
packaging
pkg of 10KU
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... IL2(3558)
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Analysis Note
在使用IL-2依赖性鼠细胞毒性T细胞系CTLL-2的细胞增殖测定中测试生物活性。
Application
人白介素2已用于评估肿瘤坏死因子受体1（TNFR1）的变化。它也已用于Tregs上的TNFR2表达。
Biochem/physiol Actions
白介素2（IL2）是一种促炎性细胞因子。它由三个亚基组成，其中β亚基对于受体介导的信号传导很重要。IL2增强T调节细胞的发育，并在抗肿瘤免疫中起关键作用。
白细胞介素-2（IL-2）是由某些T淋巴细胞亚群产生的免疫调节因子。该淋巴因子能够促进活化T细胞和相关细胞类型的长期生长。IL-2在NK细胞的激活和增殖、诱导γ-干扰素和B细胞生长因子分泌中发挥作用，并且能够调节IL-2受体的表达。
Physical form
从50 mM磷酸钠缓冲盐水（pH值7.0）中的0.2 μm过滤溶液中冻干，每0.1 mL细胞因子含有0.1%人血清白蛋白。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--人源产品
此项目有
Racha Bahri et al.
Cancers, 14(12) (2022-06-25)
The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the
TNFR1 and TNFR2 expression and induction on human Treg cells from type 1 diabetic subjects
Heinrich M, et al.
Antibodies, 4(1), 34-47 (2015)
Nader Bayda et al.
Cancers, 13(4) (2021-02-10)
The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL) in more than 80% of cases. Few studies have focused on this association and it is not clear now what role the virus plays in this pathology. We
Meera V Singh et al.
Journal of leukocyte biology, 109(4), 807-820 (2020-07-15)
In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals
The main function of IL-2 is to promote the development of T regulatory cells
Malek, Th, et al.
Journal of Leukocyte Biology, 74(6) (2003)
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