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一般描述
白介素-6是一种参与造血、炎症和免疫反应的多效性细胞因子。IL-6由巨噬细胞，树突状细胞和B细胞分泌，以响应TNF-α，PGDF和IL-1。IL-6的信号传导是由异二聚体受体IL-6R介导的，该受体由IL-6Rα（可溶性因子）和gp130（有时称为IL-6Rβ）组成。gp130是下游信号转导的关键组成部分。响应IL-6，gp130激活JAK家族，STATs，MAPK和Ras蛋白的激酶。 IL-6介导的信号传导对于T细胞和B细胞的正常发育至关重要，并且与许多疾病有关，例如类风湿关节炎，克罗恩病，脓毒症，发热，系统性红斑狼疮，骨质疏松症和胰岛素耐受。单克隆抗白介素-6抗体识别人IL-6。该抗体与重组小鼠IL-6或重组人IL-6 sR、OSM、LIF CNTF或IL-11或重组马gp130无交叉反应性。
特异性
该抗体能够中和重组人IL-6的生物活性。该抗体与重组小鼠IL-6或重组人IL-6 sR、OSM、LIF CNTF或IL-11或重组马gp130无交叉反应性。
免疫原
重组人 IL-6。
应用
单克隆抗白介素-6抗体可用于ELISA，最小值抗体浓度为4μg/ml。对于免疫印迹，可使用1-2 μg/mL的工作抗体浓度。该抗体可用于中和测定；ND50为0.01-0.15 μg/ml。为了中和来自人外周血单核细胞的IL-6，使用了2.5μ g/ml的浓度。
外形
从磷酸盐缓冲盐水中的0.2 μm过滤溶液冻干。
制备说明
使用蛋白A纯化。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
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