I7034
Monoclonal Anti-Interleukin-4 antibody produced in mouse
clone 3007, purified immunoglobulin, lyophilized powder
别名:
Anti-IL-4
产品名称
Monoclonal Anti-Interleukin-4 antibody produced in mouse, clone 3007, purified immunoglobulin, lyophilized powder
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3007, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
immunohistochemistry: 5-15.0 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IL4(3565)
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Application
Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For immunohistochemistry, a working concentration of 15 μg/ml may be used for human tissues and 5-15 μg/ml may be used for human cells. The antibody is suitable for neutralization reactions.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 specifically recognizes human interleukin-4 (12-20 kDa). It does not react with mouse IL-4.
Anti-Interleukin-4 specifically recognizes human interleukin-4 (12-20 kDa). It does not react with mouse IL-4.
Immunogen
purified, E. coli-derived recombinant human interleukin-4.
Physical form
Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.
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存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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