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一般描述
ITK (IL2-inducible T-cell kinase) is a member of the Tec family of tyrosine kinases. ITK is expressed in T-cells.
生化/生理作用
ITK (IL2-inducible T-cell kinase) is important for T-cell activation through the T-cell antigen receptor. Absence of ITK in T cells causes impairment in TCR (T cell receptor)-mediated actin polymerization, cell polarization and signaling events associated with cytoskeletal reorganization.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Lisa D Finkelstein et al.
Trends in cell biology, 14(8), 443-451 (2004-08-17)
Following stimulation, T cells undergo marked actin-dependent changes in shape that are required for productive cellular interactions and movement during immune responses. Reorganization of the actin cytoskeletal is also necessary for the formation of an immunological synapse - the convergence
Avery August et al.
The international journal of biochemistry & cell biology, 34(10), 1184-1189 (2002-07-20)
ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient
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