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质量水平
溶解性
H2O: 50 mg/mL
SMILES字符串
Cl.C1CN=C(N1)C2COc3ccccc3O2
InChI
1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChI key
MYUBYOVCLMEAOH-UHFFFAOYSA-N
基因信息
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
应用
Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
生化/生理作用
α2-adrenoceptor antagonist; I2 imidazoline receptor agonist; I1 imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Effects of idazoxan on alcohol pharmacokinetics and intoxication: a preliminary human laboratory study
Haass-Koffler C L, et al.
Alcohol, 39(4), 594-602 (2015)
Sidney P Kuo et al.
Neuron, 71(2), 306-318 (2011-07-28)
Inhibitory interneurons across diverse brain regions commonly exhibit spontaneous spiking activity, even in the absence of external stimuli. It is not well understood how stimulus-evoked inhibition can be distinguished from background inhibition arising from spontaneous firing. We found that noradrenaline
Christopher J Barnum et al.
Pharmacology, biochemistry, and behavior, 100(3), 607-615 (2011-10-08)
While L-3,4-dihydroxyphenylalanine (L-DOPA) remains the standard treatment for Parkinson's disease (PD), long-term efficacy is often compromised by L-DOPA-induced dyskinesia (LID). Recent research suggests that targeting the noradrenergic (NE) system may provide relief from both PD and LID, however, most PD
Valerio Mammoli et al.
Bioorganic & medicinal chemistry, 20(7), 2259-2265 (2012-03-01)
Aim of the present study was to obtain novel α(2)-adrenoreceptor (α(2)-AR) antagonists, possibly endowed with subtype-selectivity. Therefore, inspired by the non subtype-selective α(2)-AR antagonist idazoxan, we designed 1,4-dioxane derivatives bearing an aromatic area in position 5 or 6 and the
Kunie Nakajima et al.
Pain, 153(5), 990-997 (2012-03-20)
Antidepressants are often used for the treatment of neuropathic pain. Clinical studies suggest that the efficacy of serotonin (5-HT) and noradrenaline (NA) reuptake inhibitors (SNRIs) for neuropathic pain is greater than that of selective 5-HT reuptake inhibitors (SSRIs). In the
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