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生物来源
mouse
质量水平
重组
expressed in E. coli
方案
≥98% (SDS-PAGE)
表单
lyophilized powder
分子量
protein 15.6 kDa
包装
pkg of 0.1 mg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
颜色
white
溶解性
water: soluble 1.000 mL, clear, colorless
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Ifng(15978)
相关类别
应用
小鼠干扰素-γ 已用于：
- 体外 BMDC（骨髓源性树突状细胞）、BMM（骨髓源性巨噬细胞）和 CD11c + （CD11 抗原样家族成员 c）肺巨噬细胞的刺激
- 刺激小鼠巨噬细胞，诱导产生亚硝酸盐和硝酸盐
- 检查 CCAAT/增强子结合蛋白 β（C/EBPβ）介导的前列腺素合成酶在神经炎症中表达的变化
生化/生理作用
干扰素-γ (interferon-γ) 在天然免疫和获得性免疫应答中发挥重要作用，并有助于防御细菌感染、二型酵母和一些病毒感染。
外形
从 0.2 μm 过滤缓冲液冻干。基于蛋白质含量的包装尺寸。
分析说明
重组小鼠 IFN-γ 的生物学活性通过其抑制鼠 WEHI-279 细胞增殖的能力进行测定。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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Analytical biochemistry, 328(1), 14-21 (2004-04-15)
Preparation of a nitrate reductase lysate of Escherichia coli MC1061 to measure nitrate and nitrite in biologic fluids is described. To obtain the crude bacterial lysate containing nitrate reductase activity, E. coli MC1061 was subjected to 16-20 freeze-thawing cycles, from
S N Vogel et al.
Infection and immunity, 38(2), 681-685 (1982-11-01)
Silica has been used for many years as an agent which selectively alters macrophage functions and, as such, has been used to assess the role of macrophages in the immune response to a variety of microbial and chemically defined agents.
P W Gray et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(19), 5842-5846 (1983-10-01)
The murine immune interferon (IFN-gamma) gene was cloned and expressed under control of the simian virus 40 early promoter in the monkey COS-1 cell line. A protein is secreted from these cells having the biological, antigenic, and biochemical characteristics of
Shaoxi Yan et al.
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Inflammation causes tissue damage and promotes ventricular remodeling after myocardial infarction (MI), and the infiltration and polarization of macrophages play an important role in regulating inflammation post-MI. Here, we investigated the anti-inflammatory function of curcumin after MI and studied its
Marta Pulido-Salgado et al.
Scientific reports, 8(1), 16096-16096 (2018-11-02)
Microglia, the main resident immune cells in the CNS, are thought to participate in the pathogenesis of various neurological disorders. LPS and LPS + IFNγ are stimuli that are widely used to activate microglia. However, the transcriptomic profiles of microglia treated with
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