生物来源
rat
质量水平
重组
expressed in E. coli
检测方案
≥97% (SDS-PAGE)
形式
lyophilized powder
分子量
predicted mol wt 13.5 kDa
包装
pkg of 5 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
rat ... Il4(287287)
相关类别
生化/生理作用
白介素-4是对免疫活性细胞的生长和分化具有明显的影响的淋巴因子。IL-4又称B细胞刺激因子-1（BSF-1）、T细胞生长因子-2（TCGF-2）和肥大细胞生长因子-2（MCGF-2）。抑制VEGF和bFGF诱导的血管生成。 IL-4是由活化的T细胞亚群释放的复合糖蛋白。人和小鼠 IL-4 具有50％的氨基酸序列同源性，但它们的生物学作用是物种特异性的。
白介素-4淋巴因子对免疫活性细胞的生长和分化具有明显的影响，抑制 VEGF和bFGF诱导的血管生成。人和小鼠 IL-4 具有50％的氨基酸序列一致性，但它们的生物学作用是物种特异性的。
外形
从含有0.25 mg牛血清白蛋白的磷酸盐缓冲盐水中经0.2 μm滤膜过滤的溶液中冻干。
分析说明
通过刺激大鼠脾细胞增殖的能力来测量重组大鼠IL-4的生物活性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Monique Michels et al.
Clinical science (London, England : 1979), 134(7), 765-776 (2020-03-29)
In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of
Robert Nunan et al.
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Neurogenesis, the production of new neurons from neural stem/progenitor cells (NSPCs), occurs throughout adulthood in the dentate gyrus of the hippocampus, where it supports learning and memory. The innate and adaptive immune systems are increasingly recognized as important modulators of
Jeremy A Daniel et al.
The Journal of cell biology, 183(5), 777-783 (2008-12-03)
Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon DNA damage, an activation mechanism involving autophosphorylation has been reported to allow ATM to phosphorylate downstream
Mingming Zhang et al.
PloS one, 9(10), e109146-e109146 (2014-10-03)
It has been shown that Faecalibacterium prausnitzii (F. prausnitzii), one of the dominant intestinal bacterial flora, may protect colonic mucosa against the development of inflammation and subsequent inflammatory bowel disease (IBD), with the underlying mechanisms being unclear. The impacts of
Rebecca Winkelmann et al.
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Maturation as well as antigen-dependent activation of B cells is accompanied by alternating phases of proliferation and quiescence. We and others have previously shown that Krüppel-like factor 2 (KLF2), a regulator of T cell quiescence and migration, is upregulated in
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