I2892
艾芬地尔 (+)-酒石酸盐
NMDA antagonist
别名:
α-(4-羟基苯基)-β-甲基-4-苄基-1-哌啶乙醇 (+)-酒石酸盐
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关于此项目
线性分子式:
(C21H27NO2)2 · C4H6O6
化学文摘社编号:
分子量:
800.98
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-493-5
MDL number:
Quality level:
产品名称
艾芬地尔 (+)-酒石酸盐,
InChI
1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)
InChI key
DMPRDSPPYMZQBT-UHFFFAOYSA-N
SMILES string
OC(C(O)C(O)=O)C(O)=O.CC(C(O)c1ccc(O)cc1)N2CCC(CC2)Cc3ccccc3.CC(C(O)c4ccc(O)cc4)N5CCC(CC5)Cc6ccccc6
storage temp.
room temp
Quality Level
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
相关类别
Application
酒石酸艾芬地尔已用于：
- 检测其对KCl诱导皮层扩散性抑制(CSD)动物的作用
- 研究其对新皮质锥体细胞的电生理活性和自发脉冲的影响
- 研究其治疗效果
Biochem/physiol Actions
作用于多胺站点的 NMDA 拮抗剂；神经保护剂；α-肾上腺素能中枢和外周血管扩张剂；α 2 肾上腺素能受体配体。
Features and Benefits
该化合物是受体分类及信号转导手册上谷氨酸受体（离子通道家族）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
General description
艾芬地尔是一种苯乙醇胺，可刺激血液循环。具有抗惊厥和镇痛活性。艾芬地尔用于治疗创伤后应激障碍、脑血管病和外周动脉阻塞。它可抑制G蛋白偶联内向整流型钾通道(GIRK)，与α1肾上腺素、N-甲基-D-天冬氨酸和血清素受体相互作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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