跳转至内容
Merck
CN
所有图片(3)

主要文件

安全信息

I2643

Sigma-Aldrich

胰岛素 人

recombinant, expressed in yeast (proprietary host)

登录查看公司和协议定价
所有图片(3)

About This Item

经验公式（希尔记法）:
C257H383N65O77S6
CAS号:
11061-68-0
分子量:
5807.57
EC 号:
234-279-7
MDL编号:
MFCD00131380
UNSPSC代码:
12352202
NACRES:
NA.32
生物来源:
human
表单:
powder
方案:
≥98% (HPLC)

生物来源

human

质量水平

200

重组

expressed in yeast (proprietary host)

无菌性

non-sterile

方案

≥98% (HPLC)

表单

powder

效能

≥27.5 units/mg (dried basis)

技术

cell culture | mammalian: suitable

溶解性

0.01 M HCl: 20 mg/mL, clear, colorless

UniProt登记号

P01308

运输

ambient

储存温度

−20°C

InChI key

PBGKTOXHQIOBKM-FHFVDXKLSA-N

基因信息

human ... INS(3630)

正在寻找类似产品? 访问 产品对比指南

相关类别

应用

人胰岛素已被用于：
  • ASC（脂肪干细胞）的脂肪生成所需的培养基
  • 研究胰岛素在年轻和老年大鼠大脑中的作用。
  • 使用小鼠模型研究胰岛素对蛋白酶激活受体 2 (PAR2) 炎症作用的影响

生化/生理作用

由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。

其他说明

InChI：1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134+,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1

制备说明

This product can be solubilized in 20 mg/mL of 0.01 M HCL. After solubilizing the material , a stock solution can be stored for long term storage at -20°C in single-use aliquots. Freeze-thaw cycles should be avoided.

相关产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

胰岛素激素类产品
常规特殊物品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000395142
0000397998
0000389063
0000389064
0000356684

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What solvents can be used to make a solution of Insulin human, Product I2643?

    Insulin is readily soluble in dilute acid and alkalies.  The solubility of insulin is tested in 0.01 M hydrochloric acid at a concentration of 20 mg/mL.

  4. How can I store the solutions of Insulin human, Product I2643, and how long?

    A stock solution can be stored frozen at -20°C in single-use aliquots. Freeze-thaw cycles should be avoided.  Alternatively, it can be stored for up to 12 months at 2-8°C if it is sterile filtered through a low protein binding membrane or if it contains a suitable bacteriostat, such as 0.1% thimerosal or sodium azide.

  5. How many units of insulin are present in my vial of Insulin human, Product I2643?

    The potency is listed by lot on the Certificate of Analysis, which can be accessed through our Advanced Search Options.Generally, product I2643 has a potency of 27.5 units/mg.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Theresia Gutmann et al.
The Journal of cell biology, 219(1) (2019-11-16)
Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand-receptor interactions. While biochemistry predicts two distinct insulin binding sites, 1
Linda Adzovic et al.
Journal of neuroinflammation, 12, 63-63 (2015-04-19)
The role of insulin in the brain is still not completely understood. In the periphery, insulin can decrease inflammation induced by lipopolysaccharide (LPS); however, whether insulin can reduce inflammation within the brain is unknown. Experiments administrating intranasal insulin to young
Eric Hyun et al.
Journal of immunology (Baltimore, Md. : 1950), 184(5), 2702-2709 (2010-02-02)
Given the anti-inflammatory effects of insulin in human and animal studies done in vivo and given the signaling pathways in common between insulin and the protease-activated receptor 2 (PAR(2)), a G protein-coupled receptor, we hypothesized that insulin would have an
Leanne De Koning et al.
EMBO molecular medicine, 1(3), 178-191 (2010-01-06)
Mammalian cells contain three closely related heterochromatin protein 1 (HP1) isoforms, HP1alpha, beta and gamma, which, by analogy to their unique counterpart in Schizosaccharomyces pombe, have been implicated in gene silencing, genome stability and chromosome segregation. However, the individual importance
Per Magnus Haram et al.
Cardiovascular research, 81(4), 723-732 (2008-12-03)
The recent development of a rat model that closely resembles the metabolic syndrome allows to study the mechanisms of amelioration of the syndrome by exercise training. Here, we compared the effectiveness for reducing cardiovascular risk factors by exercise training programmes
查看所有相关文献

实验方案

Guide: Expansion & Differentiation of Human Mesenchymal

TrueGel3D® Hydrogel Plate protocol guides high-throughput culture of human adipose MSCs for screening applications.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门