I2018
单克隆抗 胰岛素 小鼠抗
clone K36AC10, ascites fluid
别名:
Insulin Antibody, Insulin Antibody - Monoclonal Anti-Insulin antibody produced in mouse
产品名称
单克隆抗 胰岛素 小鼠抗, clone K36AC10, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
K36AC10, monoclonal
contains
15 mM sodium azide
species reactivity
feline, human, rat, horse, rabbit, guinea pig, bovine, monkey, sheep, canine, pig
technique(s)
dot blot: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human or animal pancreas
radioimmunoassay: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... INS(3630)
Application
小鼠抗胰岛素单克隆抗体可用于ELISA蛋白PIN芯片测定，研究人α晶体和胰岛素的相互作用。它可用于大鼠白细胞和肥大细胞的流式细胞分析。
小鼠抗胰岛素单克隆抗体已用于免疫印迹和 ELISA 试验。
Biochem/physiol Actions
胰岛素是一种重要的调控激素，在代谢过程、葡萄糖、氨基酸和某些离子的运输中发挥着重要作用。它还参与核酸和蛋白质的合成。胰岛素的生物学效应由胰岛素受体介导，涉及多个主要信号通路。
胰岛素是一种重要的调控激素，在代谢过程、葡萄糖、氨基酸和某些离子的运输中发挥着重要作用。它还参与核酸和蛋白质的合成。胰岛素的生物学效应由胰岛素受体介导，涉及多个主要信号通路。胰岛素分泌或功能异常会导致糖尿病、肥胖等碳水化合物代谢疾病。目前确知，胰岛素可以刺激细胞分裂。
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
General description
在RIA和免疫细胞化学中，该抗体可与胰岛素特异性反应。它与人胰岛素原具有交叉反应性。在RIA中，该抗体与胰岛素结合的亲和力常数为8.8 × 109 M-1。
胰岛素基因定位于人类染色体 11p15.5
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
H Keilacker et al.
Biomedica biochimica acta, 45(8), 1093-1102 (1986-01-01)
We investigated four insulin-specific hybridoma antibodies with respect to their kinetic properties as well as the binding behaviour of some combinations of them. From equilibrium binding data all but one antibodies were shown to bear homogeneous binding sites. They revealed
Sandra K Szlapinski et al.
The Journal of physiology, 597(16), 4237-4250 (2019-06-18)
Pancreatic β-cell dysfunction is hypothesized to be the significant determinant of gestational diabetes pathogenesis, however pancreatic samples from patients are scarce. This study reports a novel mouse model of gestational glucose intolerance in pregnancy, originating from previous nutrition restriction in
Proinsulin-specific monoclonal antibodies. Immunocytochemical application as beta-cell markers and as probes for conversion.
O D Madsen
Diabetes, 36(10), 1203-1211 (1987-10-01)
Xiao-Yi Zeng et al.
PloS one, 7(7), e42115-e42115 (2012-08-04)
The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid selected from our recent screening, on hyperglycemia in type-2 diabetic mice. C57BL/6J mice were fed a high-fat diet followed by low doses of streptozotocin to generate a
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.
Wang F, et al.
Diabetes, 50(11), 2514-2520 (2001)
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