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生物来源
human
质量水平
重组
expressed in E. coli
检测方案
≥97% (HPLC and SDS-PAGE)
形式
lyophilized powder
效能
≤1.0 ng/mL ED50/EC50
质量
endotoxin tested
分子量
15 kDa
包装
pkg of 10 and 50 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
≤0.1 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
human ... IL3(3562)
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相关类别
生化/生理作用
白介素3（IL-3）是一种多功能蛋白，起初被称为克隆形成单位刺激活性（CFU-SA），由活化的T淋巴细胞产生。IL-3在多能造血祖细胞的早期发育中可支持多谱系克隆的形成。IL-3已显示出可从琼脂悬浮的骨髓细胞诱导巨噬细胞、嗜中性粒细胞、肥大细胞和巨核细胞的克隆形成。IL-3也可与IL-2发生互作，以刺激T淋巴细胞的生长并诱导活化B细胞分泌IgG。IL-3的其他同义词包括泛特异性造血素、多克隆刺激因子、肥大细胞生长因子、爆发促进活性、组胺生成细胞刺激因子、P细胞刺激因子和WEHI-3因子。
外形
无添加剂冻干。已经过0.2 μm滤器过滤。
分析说明
通过剂量依赖性刺激人TF-1细胞的增殖来测量生物活性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
常规特殊物品
Bingrui Wang et al.
Cell discovery, 8(1), 41-41 (2022-05-10)
Ribosomal protein dysfunction causes diverse human diseases, including Diamond-Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-specific defects, are still poorly understood. In the present study, we
Ding Wang et al.
iScience, 26(6), 106917-106917 (2023-06-28)
The role of SET domain containing 7 (SETD7) during human hematopoietic development remains elusive. Here, we found that deletion of SETD7 attenuated the generation of hematopoietic progenitor cells (HPCs) during the induction of hematopoietic differentiation from human embryonic stem cells
S Yousefi et al.
Allergy, 70(9), 1184-1188 (2015-06-05)
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report
Hai Zhou et al.
Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production
Amy H Lin et al.
Journal of virology, 88(17), 10066-10077 (2014-06-27)
We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
实验方案
产生人诱导多能干细胞（iPSC）的干细胞重编程实验方案，包括基于病毒和非病毒RNA的方法。
Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.
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