I0879
肌苷 5′-三磷酸盐 三钠盐
≥95%
别名:
特发性血小板减少性紫癜
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关于此项目
经验公式（希尔记法）:
C10H12Na3N4O14P3
化学文摘社编号:
分子量:
574.11
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
肌苷 5′-三磷酸盐 三钠盐, ≥95%
InChI
1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
SMILES string
[Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
InChI key
RIERCUPIZLBNFQ-UHFFFAOYSA-N
assay
≥95%
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... HRAS(3265)
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Application
肌苷 5′-三磷酸盐 (ITP) 用于各种酶和化学过程对 ATP 和 GTP 脱氨作用影响的研究。ITP 可作为研究核苷-5′ 的特异性和动力学的底物-三磷酸酶和 atp 酶。ITP 也用于研究各种 atp 酶和 gtp 酶的激活。
肌苷 5′-本文研究了三磷酸三钠盐对人外周血淋巴细胞染色体畸变率、有丝分裂率、姐妹染色单体互换 (SCE) 频率、第一分裂中期 (X1)、第二分裂中期 (X2) 和第三分裂中期 (X3) 的影响。
Biochem/physiol Actions
肌苷 5′——三磷酸盐 (ITP) 具有支持效应系统启动的能力。可阻止鸟苷 5′——三磷酸鸟苷 (GTP) 水解，由转导素 (TD) 催化。与 GTP 相比，ITP 能熟练诱导透化细胞分泌。ITP 代替 GTP 可用于呼肠孤病毒转录的起始和延伸步骤。ITP 在 G 蛋白的激活中也能取代 GTP。
Preparation Note
由细菌 ATP 制备
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hui-Yu Liu et al.
Biochemical pharmacology, 64(4), 583-593 (2002-08-09)
The G(s)-proteins G(salpha-short) (G(salphaS)) and G(salpha-long) (G(salphaL)), and the olfactory G(s) protein (G(alphaolf)) mediate activation of adenylyl cyclase by the beta(2)-adrenoceptor (beta(2)AR). Early studies showed that the purine nucleotides GTP, ITP, and XTP differentially support receptor-mediated adenylyl cyclase activation in
H J Wieker et al.
Biochimica et biophysica acta, 806(1), 35-41 (1985-01-23)
The hydrolysis of MgATP and MgITP by mitochondrial F1-ATPase from Saccharomyces cerevisiae is competitively inhibited by alpha, beta-CrADP, alpha, beta, gamma-CrATP and beta, gamma-CrATP. The apparent K1 values of the three complexes are in the range of the half-saturating MgATP
R Rao et al.
The Journal of biological chemistry, 263(12), 5569-5573 (1988-04-25)
The stoichiometry of nucleotide binding to the isolated alpha- and beta-subunits of Escherichia coli F1-ATPase was investigated using two experimental techniques: (a) titration with fluorescent trinitrophenyl (TNP) derivatives of AMP, ADP, and ATP and (b) the centrifuge column procedure using
Jimin Zheng et al.
Structure (London, England : 1993), 13(10), 1511-1520 (2005-10-12)
Inosine triphosphate (ITP) and xanthosine triphosphate (XTP) are formed upon deamination of ATP and GTP as a result of exposure to chemical mutagens and oxidative damage. Nucleic acid synthesis requires safeguard mechanisms to minimize undesired lethal incorporation of ITP and
T Toyo-oka
Circulation research, 49(6), 1350-1355 (1981-12-01)
The contraction of cardiac muscle that has been treated with glycerol requires Ca2+ (pCa 8-5), when MgATP is used as a substrate. In contrast, this preparation contracts, even in the absence of Ca2+ (pCa 8-10), when ATP is replaced by
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