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方案
≥99% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: soluble 28 mg/mL
H2O: soluble 4.5 mg/mL
储存温度
2-8°C
SMILES字符串
CC(C)C(=O)c1c(nn2ccccc12)C(C)C
InChI
1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChI key
ZJVFLBOZORBYFE-UHFFFAOYSA-N
基因信息
human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)
生化/生理作用
Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Aldric T Hama et al.
Journal of neurotrauma, 29(3), 600-610 (2011-08-03)
Ibudilast, an asthma drug, has demonstrated antinociceptive effects in several rat models of peripheral neuropathic pain, and a proposed mechanism of action is the inhibition of release of the cytokine tumor necrosis factor-α (TNF-α) from activated spinal microglia. Spinal glial
Jennifer H Benbow et al.
The Journal of biological chemistry, 287(45), 37907-37916 (2012-09-19)
Peripheral neuropathy is one of the most severe and irreversible side effects caused by treatment from several chemotherapeutic drugs, including paclitaxel (Taxol®) and vincristine. Strategies are needed that inhibit this unwanted side effect without altering the chemotherapeutic action of these
Michelle Kiebala et al.
PloS one, 6(4), e18633-e18633 (2011-04-16)
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND) occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator of transcription (Tat), in the central nervous system (CNS). Given the need for novel adjunctive therapies for
Hwa Yoon et al.
Biomedical chromatography : BMC, 24(3), 324-328 (2009-07-25)
A simple, accurate, precise and cost effective reversed-phase HPLC method was developed to determine the concentration of ibudilast in human serum. Ibudilast and an internal standard, butyl 4-hydroxybenzoate, were extracted by liquid-liquid extraction with methyl tert-butyl ether. HPLC analysis was
Sarah E Snider et al.
European journal of pharmacology, 701(1-3), 124-130 (2013-02-05)
Neuroinflammation induced by activated microglia and astrocytes can be elicited by drugs of abuse. Methamphetamine administration activates glial cells and increases proinflammatory cytokine production, and there is recent evidence of a linkage between glial cell activation and drug abuse-related behavior.
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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