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方案
≥99% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: soluble 28 mg/mL
H2O: soluble 4.5 mg/mL
储存温度
2-8°C
SMILES字符串
CC(C)C(=O)c1c(nn2ccccc12)C(C)C
InChI
1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChI key
ZJVFLBOZORBYFE-UHFFFAOYSA-N
基因信息
human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)
生化/生理作用
Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Robert J Fox
Neurology, 74(13), 1018-1019 (2010-03-05)
F Barkhof et al.
Neurology, 74(13), 1033-1040 (2010-03-05)
Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS. In this multicenter, double-blind, phase
Masahiro Noguchi et al.
Biological & pharmaceutical bulletin, 32(11), 1924-1927 (2009-11-03)
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal
P Rolan et al.
Expert opinion on pharmacotherapy, 10(17), 2897-2904 (2009-11-26)
Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS
Michelle Mo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(11), 4696-4709 (2012-08-15)
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect that occurs in many patients undergoing chemotherapy. It is often irreversible and frequently leads to early termination of treatment. In this study, we have identified two compounds, lithium and ibudilast, that
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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